Clinical Significance of Coagulation Assays in Metastatic Pancreatic Adenocarcinoma

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• 作者：Faruk Tas (1)
  Senem Karabulut (1)
  Elif Bilgin (1)
  Leyla Klc (1)
  Rumeysa Ciftci (1)
  Derya Duranyildiz (1)
  
• 关键词：Coagulation ; Test ; Pancreatic adenocarcinoma ; Metastatic
• 刊名：Journal of Gastrointestinal Cancer
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：44
• 期：4
• 页码：404-409
• 全文大小：
• 作者单位：Faruk Tas (1)
  Senem Karabulut (1)
  Elif Bilgin (1)
  Leyla Klc (1)
  Rumeysa Ciftci (1)
  Derya Duranyildiz (1)
  
  1. Institute of Oncology, University of Istanbul, Capa, 34390, Istanbul, Turkey
  
• ISSN：1941-6636

文摘

Purpose Activated coagulation and fibrinolytic system in cancer patients is associated with tumor stroma formation and metastasis in different cancer types. The aim of this study is to explore the correlation of blood coagulation tests for various clinicopathologic factors in patients with metastatic pancreatic adenocarcinoma (MPA). Material A total of 17 MPA patients were enrolled into the study. All the patients were treatment-nave. Pretreatment blood coagulation tests including prothrombin time, activated partial thromboplastin time (APTT), international normalized ratio (INR), D-dimer, fibrinogen levels, and platelet counts were evaluated. Control group comprised 50 age- and sex-matched individuals without history of malignancy and coagulation disorder. Results Median age of diagnosis was 59years old (range, 352). The plasma level of all coagulation factors revealed statistically significant difference between patient and control group (p<0.01). Anemic patients had associated with higher D-dimer levels (p=0.001). Similarly, the ones with elevated serum CA19-9 exhibited significantly higher D-dimer values (p=0.011). For APTT, significant differences were found in both between gender of patients (p=0.01) and response to chemotherapy (p=0.01). The patients with elevated erythrocyte sedimentation rates had associated with higher INR (p=0.05). Univariate analysis of survival revealed that the patients with unresponsive to chemotherapy (p=0.06) and higher INR (p=0.078) had poor overall outcome. Conclusion Serum D-dimer level is elevated among MPA patients with higher serum CA19-9 and higher INR levels seem to be a poor prognostic factor in MPA.