Phenolic profiles, antioxidant capacity, and acetylcholinesterase inhibitory activity of eight South African seaweeds

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• 作者：Kannan R. R. Rengasamy ; Stephen O. Amoo ; Adeyemi O. Aremu…
• 关键词：Alzheimer’s disease ; AChE inhibitors ; Phenolics ; Macroalgae ; UHPLC ; MS/MS
• 刊名：Journal of Applied Phycology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：27
• 期：4
• 页码：1599-1605
• 全文大小：177 KB
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• 作者单位：Kannan R. R. Rengasamy (1)
  Stephen O. Amoo (1)
  Adeyemi O. Aremu (1)
  Wendy A. Stirk (1)
  Ji?í Gruz (2)
  Michaela ?ubrtová (2)
  Karel Dole?al (2)
  Johannes Van Staden (1)
  
  1. Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville, 3209, South Africa
  2. Laboratory of Growth Regulators & Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacky University & Institute of Experimental Botany AS CR, ?lechtitel? 11, 783 71, Olomouc, Czech Republic
  
• 刊物主题：Plant Sciences; Freshwater & Marine Ecology; Plant Physiology; Ecology;
• 出版者：Springer Netherlands
• ISSN：1573-5176

文摘

In the search for new, safe, and natural sources as antioxidant and acetylcholinesterase (AChE) inhibitors, eight seaweeds were collected from the intertidal region in KwaZulu-Natal, South Africa and screened. Their total phenolic, flavonoid, and condensed tannin contents were determined, and the specific phenolic acids were identified. The highest total phenolics, flavonoids, and condensed tannin were recorded in Rhodomelopsis africana (7.89?mg gallic acid equivalents g?), Halimeda cuneata (3.64?mg catechin equivalents g?), and Codium duthieae (0.60?mg cyanide chloride equivalents g?), respectively. Based on UHPLC-MS/MS, different concentrations of protocatechuic acid, p-hydroxybenzoic acid, and m-hydroxybenzoic acid were quantified in the seaweeds. The highest radical scavenging ability and oxygen radical absorbance capacity (ORAC) were observed in red Gelidium foliaceum (52.2?%) and green C. duthieae (44?μmol TE g?), respectively. In terms of AChE inhibition, the green H. cuneata exhibited greatest bioactivity (IC50--0?μg?mL?). Overall, the findings suggest that these seaweeds could be potential candidates as new sources of natural antioxidant and AChE inhibitors.