Low serum insulin-like growth factor-1 in patients with erectile dysfunction

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• 作者：Alper Otunctemur ; Emin Ozbek ; Suleyman Sahin ; Levent Ozcan…
• 关键词：Endothelial dysfunction ; Erectile dysfunction ; Insulin ; like growth factor ; 1 ; International Index of Erectile Function Score ; 5 ; Dysfonction endothéliale ; Dysfonction érectile ; Insulin ; like Growth Factor ; 1 ; IIEF ; 5
• 刊名：Basic and Clinical Andrology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：26
• 期：1
• 全文大小：414 KB
• 参考文献：1.O’Donnell AB, Araujo AB, McKinlay JB. The health of normally aging men: the Massachusetts male aging study (1987–2004). Exp Gerontol. 2004;39:975–84.PubMed CrossRef
  2.Lewis RW, Fugl-Meyer KS, Corona G, Hayes RD, Laumann EO, Moreira ED Jr, et al. Definitions/epidemiology/ risk factors for sexual dysfunction. J Sex Med. 2010;7:1598–607.PubMed CrossRef
  3.Kaiser DR, Billups K, Mason C, Wetterling R, Lundberg JL, Bank AJ. Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease. J Am Coll Cardiol. 2004;43:179–84.PubMed CrossRef
  4.Ciccone MM, Iacoviello M, Puzzovivo A, Scicchitano P, Monitillo F, De Crescenzo F, et al. Clinical correlates of endothelial function in chronic heart failure. Clin Res Cardiol. 2011;100(6):515–21.PubMed CrossRef
  5.Chiurlia E, D'Amico R, Ratti C, Granata AR, Romagnoli R, Modena MG. Subclinical coronary artery atherosclerosis in patients with erectile dysfunction. J Am Coll Cardiol. 2005;46:1503–6.PubMed CrossRef
  6.Delafontaine P, Song YH, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol. 2004;24:435.PubMed CrossRef
  7.Clemmons DR. Insulin-like growth factor binding proteins and their role in controlling IGF actions. Cytokine Growth Factor Rev. 1997;8:45–62.PubMed CrossRef
  8.LeRoith D. Insulin-like growth factor I receptor signaling—overlapping or redundant pathways? Endocrinology. 2000;141:1287–8.PubMed
  9.Jung GW, Kwak JY, Yoon S, Yoon JH, Lue TF. IGF-I and TGF-beta2 have a key role on regeneration of nitric oxide synthase (NOS)-containing nerves after cavernous neurotomy in rats. Int J Impot Res. 1999;11:247–59.PubMed CrossRef
  10.Bochinski D, Hsieh PS, Nunes L, Lin GT, Lin CS, Spencer EM, et al. Effect of insulin-like growth factor-1 and insulinlike growth factor binding protein-3 complex in cavernous nerve cryoablation. Int J Impot Res. 2004;16:418–23.PubMed CrossRef
  11.El-Sakka AI, Lin CS, Chui RM, Dahiya R, Lue TF. Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model. Int J Impot Res. 1999;11:123–32.PubMed CrossRef
  12.Sukhanov S, Higashi Y, Shai SY, Blackstock C, Galvez S, Vaughn C, et al. Differential requirement for nitric oxide in IGF-1-induced anti-apoptotic, anti-oxidant and anti-atherosclerotic effects. FEBS Lett. 2011;585:3065–72.PubMed PubMedCentral CrossRef
  13.Maison P, Balkau B, Souberbielle JC, Cunin P, Vol S, Macquin-Mavier I, et al. Evidence for distinct effects of GH and IGF-I in the metabolic syndrome. Diabet Med. 2007;24:1012–8.PubMed CrossRef
  14.Castela Â, Soares R, Rocha F, Medeiros R, Ribeiro R, Monteiro C, et al. Mol Genet Metab. 2012;105:255–62.PubMed CrossRef
  15.Thompson A, Gao P, Orfei L, Watson S, Di Angelantonio E, Kaptoge S, et al. Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet. 2010;375:1536–44.PubMed CrossRef
  16.Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB, et al. Erectile dysfunction and coronary risk factors: Prospective results from the Massachusetts male aging study. Prev Med. 2000;30:328–38.PubMed CrossRef
  17.Michel T, Vanhoutte PM. Cellular signaling and NO production. Pflugers Arch. 2010;459:807–16.PubMed PubMedCentral CrossRef
  18.Shai SY, Sukhanov S, Higashi Y, Vaughn C, Rosen CJ, Delafontaine P. Low circulating insulin-like growth factor I increases atherosclerosis in ApoE-deficient mice. Am J Physiol Heart Circ Physiol. 2011;300:1898–906.CrossRef
  19.Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med. 1989;320:1025–30.PubMed CrossRef
  20.Xie Y, Garban H, Ng C, Rajfer J, Gonzalez-Cadavid NF. Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat. J Urol. 1997;157:1121–6.PubMed CrossRef
  21.Vorwerk P, Oh Y, Lee PD, Khare A, Rosenfeld RG. Synthesis of IGFBP-3 fragments in a baculovirus system and characterization of monoclonal anti- IGFBP-3 antibodies. J Clin Endocrinol Metab. 1997;82:2368–70.PubMed CrossRef
  22.Soh J, Katsuyama M, Ushijima S, Mizutani Y, Kawauchi A, Yabe-Nishimura C, et al. Localization of increased insulin-like growth factor binding protein-3 in diabetic rat penis: Implications for erectile dysfunction. Urology. 2007;70:1019–23.PubMed CrossRef
  23.Pu XY, Zheng XG, Zhang Y, Xiao HJ, Xu ZP, Liu JM, et al. Higher expression of mRNA and protein of insulin-like growth factor binding protein-3 in old rat penile tissues: implications for erectile dysfunction. J Sex Med. 2011;8:2181–90.PubMed CrossRef
  24.Christ GJ. The penis as a vascular organ. The importance of corporal smooth muscle tone in the control of erection. Urol Clin North Am. 1995;22:727–45.PubMed
  25.Andersson KE. Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol. 2003;170:S6–14.PubMed CrossRef
  26.Pu XY, Wang XH, Gao WC, Yang ZH, Li SL, Wang HP, et al. Insulin-Like Growth Factor-1 Restores Erectile Function in Aged Rats: Modulation the Integrity of Smooth Muscle and Nitric Oxide-Cyclic Guanosine Monophosphate Signaling Activity. J Sex Med. 2008;5:1345–54.PubMed CrossRef
  27.Kinlay S, Libby P, Ganz P. Endothelial function and coronary artery disease. Curr Opin Lipidol. 2001;12:383–9.PubMed CrossRef
  28.Anderson TJ, Gerhard MD, Meredith IT, Charbonneau F, Delagrange D, Creager MA, et al. Systemic nature of endothelial dysfunction in atherosclerosis. Am J Cardiol. 1995;75:71B–4.PubMed CrossRef
  29.Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111–5.PubMed CrossRef
  30.Sullivan ME, Thompson CS, Dashwood MR, Khan MA, Jeremy JY, Morgan RJ, et al. Nitric oxide and penile erection: Is erectile dysfunction another manifestation of vascular disease? Cardiovasc Res. 1999;43:658–65.PubMed CrossRef
  31.Jung GW, Kwak JY, Kim IH, Koo MY, Park JI, Yoon S, et al. The role of growth factor on regeneration of nitric oxide synthase (nos)—Containing nerves after cavernous neurotomy in the rats. Int J Impot Res. 1999;11:227–35.PubMed CrossRef
  32.Marfella R, Nappo F, De Angelis L, Paolisso G, Tagliamonte MR, Giugliano D. Hemodynamic effects of acute hyperglycemia in type 2 diabetic patients. Diabetes Care. 2000;23:658–63.PubMed CrossRef
  33.Gockerman A, Prevette T, Jones JI, Clemmons DR. Insulin like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II. Endocrinology. 1995;136:4168–73.PubMed
  34.Foteinos G, Hu Y, Xiao Q, Metzler B, Xu Q. Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice. Circulation. 2008;117:1856–63.PubMed CrossRef
  35.Thum T, Fleissner F, Klink I, Tsikas D, Jakob M, Bauersachs J, et al. Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I. J Clin Endocrinol Metab. 2007;92:4172–9.PubMed CrossRef
  36.Jeremy JY, Jones RA, Koupparis AJ, Hotston M, Persad R, Angelini GD, et al. Reactive oxygen species and erectile dysfunction: Possible role of NADPH oxidase. Int J Impot Res. 2007;19:265–80.PubMed CrossRef
  37.Burnett AL. Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health. J Androl. 2008;29:3–14.PubMed CrossRef
  38.Jia SJ, Jiang DJ, Hu CP, Zhang XH, Deng HW, Li YJ. Lysophosphatidylcholine-induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells. Vascul Pharmacol. 2006;44:143–8.PubMed CrossRef
  39.Csiszar A, Labinskyy N, Perez V, Recchia FA, Podlutsky A, Mukhopadhyay P, et al. Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice. Am J Physiol Heart Circ Physiol. 2008;295:H1882–94.PubMed PubMedCentral CrossRef
  40.Sukhanov S, Higashi Y, Shai SY, Vaughn C, Mohler J, Li Y, et al. IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:2684–90.PubMed CrossRef
  
• 作者单位：Alper Otunctemur (1)
  Emin Ozbek (1)
  Suleyman Sahin (1)
  Levent Ozcan (2)
  Murat Dursun (1)
  Emre Can Polat (3)
  Mustafa Cekmen (4)
  Ozgur Doga Ozsoy (4)
  Mustafa Erkoc (1)
  Eyup Danis (1)
  Muammer Bozkurt (1)
  
  1. Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey
  2. Department of Urology, Derince Training and Research Hospital, Kocaeli, Turkey
  3. Department of Urology, Istanbul Medipol University, School of Medicine, Istanbul, Turkey
  4. Department of Biochemistry, Kocaeli University, School of Medicine, Kocaeli, Turkey
  
• 刊物主题：Urology/Andrology; Reproductive Medicine; Endocrinology; Surgery; Gynecology;
• 出版者：BioMed Central
• ISSN：2051-4190

文摘

Objective Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED.