Preserved otolith organ function in caspase-3-deficient mice with impaired horizontal semicircular canal function

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• 作者：Patrick A. Armstrong ; Scott J. Wood ; Naoki Shimizu…
• 关键词：Vestibulo ; ocular reflex ; Counter rotation ; Pseudo off ; vertical axis rotation ; Otolith ; ocular response ; Mice ; Caspase ; 3
• 刊名：Experimental Brain Research
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：233
• 期：6
• 页码：1825-1835
• 全文大小：1,531 KB
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  Jones T
• 作者单位：Patrick A. Armstrong (1) (2)
  Scott J. Wood (1) (3)
  Naoki Shimizu (1)
  Kael Kuster (2)
  Adrian Perachio (1)
  Tomoko Makishima (1)
  
  1. Department of Otolaryngology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-0521, USA
  2. School of Medicine, University of Texas Medical Branch, Galveston, TX, USA
  3. Azusa Pacific University, Azusa, CA, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1106

文摘

Genetically engineered mice are valuable models for elucidation of auditory and vestibular pathology. Our goal was to establish a comprehensive vestibular function testing system in mice using: (1) horizontal angular vestibulo-ocular reflex (hVOR) to evaluate semicircular canal function and (2) otolith-ocular reflex (OOR) to evaluate otolith organ function and to validate the system by characterizing mice with vestibular dysfunction. We used pseudo off-vertical axis rotation to induce an otolith-only stimulus using a custom-made centrifuge. For the OOR, horizontal slow-phase eye velocity and vertical eye position were evaluated as a function of acceleration. Using this system, we characterized hVOR and OOR in the caspase-3 (Casp3) mutant mice. Casp3 ??/sup> mice had severely impaired hVOR gain, while Casp3 +/?/sup> mice had an intermediate response compared to WT mice. Evaluation of OOR revealed that at low-to-mid frequencies and stimulus intensity, Casp3 mutants and WT mice had similar responses. At higher frequencies and stimulus intensity, the Casp3 mutants displayed mildly reduced otolith organ-related responses. These findings suggest that the Casp3 gene is important for the proper function of the semicircular canals but less important for the otolith organ function.