Detection of autoantibodies to DSF70/LEDGFp75 in Mexican Hispanics using multiple complementary assay platforms

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• 作者：Mónica Vázquez-Del Mercado ; Eduardo Gómez-Bañuelos…
• 关键词：DFS70 ; LEDGF/p75 ; Autoantibodies ; Frequency ; Mexican ; Hispanics ; Multiple assay platforms
• 刊名：Autoimmunity Highlights
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：8
• 期：1
• 全文大小：1538KB
• 刊物主题：Immunology;
• 出版者：Springer International Publishing
• ISSN：2038-3274
• 卷排序：8

文摘

PurposeAntinuclear autoantibodies (ANA) targeting the dense fine speckled antigen DFS70, also known as lens epithelium-derived growth factor p75 (LEDGF/p75), are attracting attention due to their low frequency in systemic rheumatic diseases but increased frequency in clinical laboratory referrals and healthy individuals (HI). These ANA specifically recognize the stress protein DFS70/LEDGFp75, implicated in cancer, HIV-AIDS, and inflammation. While their frequency has been investigated in various ethnic populations, there is little information on their frequency among Hispanics/Latinos. In this study, we determined the frequency of anti-DFS70/LEDGFp75 autoantibodies in Mexican Hispanics using multiple detection platforms.