New strategy to control cell migration and metastasis regulated by CCN2/CTGF

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• 作者：Diego Pinheiro Aguiar (22)
  Gabriel Correa de Farias (22)
  Eduardo Branco de Sousa (22)
  Juliana de Mattos Coelho-Aguiar (23)
  Julie Calixto Lobo (22)
  Priscila Ladeira Casado (22)
  Maria Eug锚nia Leite Duarte (22)
  Jos茅 Garcia Ribeiro Abreu Jr (23)
  
  22. Research Division ; National Institute of Traumatology and Orthopedics ; Rio de Janeiro ; RJ ; Brazil
  23. Program of Cell and Developmental Biology ; Institute of Biomedical Sciences ; Federal University of Rio de Janeiro ; Rio de Janeiro ; RJ ; Brazil
  
• 关键词：CCN2 ; CTGF ; Adhesion ; Migration and Metastasis
• 刊名：Cancer Cell International
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：901 KB
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• 刊物主题：Cancer Research; Cell Biology;
• 出版者：BioMed Central
• ISSN：1475-2867

文摘

Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF seems to be a prognostic marker for cancer. In addition, here we intend to discuss recent discoveries and a new strategy to develop therapies against CCN2/CTGF, in order to treat cancer metastasis.