Osteoprotegerin mediates tumor-promoting effects of Interleukin-1beta in breast cancer cells
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- 作者：Stephanie Tsang Mui Chung ; Dirk Geerts ; Kim Roseman ; Ashleigh Renaud…
- 关键词：Breast cancer ; Inflammation ; Interleukin ; 1beta ; Metastasis ; Osteoprotegerin ; p38 MAPK ; p42/44 MAPK
- 刊名：Molecular Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1293KB
- 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1476-4598
- 卷排序：16
文摘
BackgroundIt is widely recognized that inflammation promotes breast cancer invasion and metastasis. Given the complex nature of the breast tumor inflammatory microenvironment, much remains to be understood of the molecular mechanisms that govern these effects. We have previously shown that osteoprotegerin knockdown in breast cancer cells resulted in reduced invasion and metastasis. Here we present novel insight into the role of osteoprotegerin in inflammation-driven tumor progression in breast cancer by investigating the link between osteoprotegerin, macrophages and the potent pro-inflammatory cytokine Interleukin-1beta.