Efficacy and safety of re-induction therapy with bevacizumab and paclitaxel for metastatic breast cancer

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• 作者：Tetsuhiro Yoshinami ; Toshinari Yagi ; Jun Okuno ; Nobuyoshi Kittaka…
• 关键词：Metastatic breast cancer ; Bevacizumab with paclitaxel ; Re ; induction therapy
• 刊名：Breast Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：147-151
• 全文大小：
• 刊物主题：Surgical Oncology; Oncology; Surgery; Cancer Research;
• 出版者：Springer Japan
• ISSN：1880-4233
• 卷排序：24

文摘

BackgroundIn many trials (including E2100), bevacizumab (Bmab) monotherapy has been continued if toxicity of paclitaxel (PTX) becomes unacceptable during combined treatment with Bmab and PTX. When progression occurs on Bmab monotherapy, one possible option is re-induction with the combination of Bmab and PTX (rBP therapy), because PTX was previously stopped due to toxicity rather than progression. However, we have no data about rBP therapy. Therefore, we investigated the efficacy and safety of rBP therapy in this study.