Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441

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• 作者：Mikihisa Takano ; Natsumi Sugimoto ; Carsten Ehrhardt…
• 关键词：alveolar epithelial cells ; Gly ; Sar uptake ; proton ; coupled oligopeptide transporter ; pulmonary drug disposition ; transcellular transport
• 刊名：Pharmaceutical Research
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：32
• 期：12
• 页码：3916-3926
• 全文大小：2,522 KB
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• 作者单位：Mikihisa Takano (1)
  Natsumi Sugimoto (1)
  Carsten Ehrhardt (2)
  Ryoko Yumoto (1)
  
  1. Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan
  2. School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Panoz Institute, Dublin 2, Ireland
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Pharmacy
  Biochemistry
  Medical Law
  Biomedical Engineering
  
• 出版者：Springer Netherlands
• ISSN：1573-904X

文摘

Purpose The peptide transporter PEPT2 is expressed in alveolar type II epithelial cells. So far, however, no appropriate alveolar epithelial cell line for studying PEPT2 function has been known. In this study, we examined the functional expression of PEPT2 in the human distal lung epithelial cell line NCl-H441 (H441).