Effects of a specially pulsed electric field on an animal model of wound healing
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- 作者：Kenan Cinar ; Selcuk Comlekci and Nurgul Senol
- 关键词：Pulsed electric field ; Wound healing ; Mouse ; Pure electric field stimulation ; Parallel plates
- 刊名：Lasers in Medical Science
- 出版年：2009
- 出版时间：September, 2009
- 年：2009
- 卷：24
- 期：5
- 页码：735-740
- 全文大小：284.2 KB
文摘
The possible beneficial effects of a specially pulsed electric field (PEF) on wound healing were investigated in this study. We made a pair of triangular, full-thickness, dorsal incisions in the skin of 32 healthy male mice (one control group and three exposure groups). The treatment groups were kept between parallel plates in a partially insulated exposed environment. Group I was exposed to an electric field intensity of 10 kV/m, group II was exposed to 1.9 kV/m, and group III was exposed to 0.9 kV/m. PEFs were applied to the subjects for 20–22 h and 8 consecutive days. We determined the differences in wound recovery between the groups based on the following parameters: collagen fiber density, inflammatory infiltration density, capillary proliferation, and existence of exudates. We found that a 0.9 kV/m–1.9 kV/m chopped direct current (DC) electric field with a 30 ¦Ìs repetition time favorably affected collagen synthesis and wound recovery. Despite the intensity of 0.9–1.9 kV/m, PEF accelerated healing, but 10 kV/m decelerated this recovery process.