Application of spinel-structured MgFe2O4 nanoparticles for simultaneous electrochemical determination diclofenac and morphine
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- 作者：Fatemeh Basiri ; Masoumeh Taei
- 关键词：Magnesium ferrite ; Multi ; walled carbon nanotubes ; Cyclic voltammetry ; Differential pulse voltammetry ; Chronoamperometry ; Diclofenac ; Morphine ; Electrochemical impedance spectroscopy
- 刊名：Microchimica Acta
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：184
- 期：1
- 页码：155-162
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Nanochemistry; Nanotechnology; Characterization and Evaluation of Materials; Analytical Chemistry; Microengineering;
- 出版者：Springer Vienna
- ISSN：1436-5073
- 卷排序：184
文摘
The paper describes a sensitive method for simultaneous sensing of morphine (MOR) and diclofenac (DCF). The surface of a MgFe2O4/graphite paste electrode was modified with multi-walled carbon nanotubes, and the resulting sensor was characterized by cyclic voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance spectroscopy. The electrode showed an efficient synergistic effect in term of oxidation of DCF and MOR, with sharp oxidation peaks occurring at +0.370 and 0.540 V (vs Ag/AgCl) at pH 7.0. The calibration plot for MOR is linear in the 50 nM to 920 μM concentration range, and the detection limit is 10 nM (at a signal-to-noise ratio of 3). The respective data for DCF are 100 nM to 580 μM, with a 60 nM LOD. The sensor was applied to the determination of MOR and DCF in spiked serum and urine samples, with recoveries ranging between 91.4 and 100.7 %.