Identification of new pyrrole alkaloids from the fruits of Lycium chinense

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• 作者：Ui Joung Youn ; Joo Yun Lee ; Yun-Seo Kil ; Ah-Reum Han…
• 关键词：Lycium chinense ; Solanaceae ; Pyrrole alkaloid ; ECD ; Absolute configuration
• 刊名：Archives of Pharmacal Research
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：39
• 期：3
• 页码：321-327
• 全文大小：523 KB
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• 作者单位：Ui Joung Youn (1)
  Joo Yun Lee (2)
  Yun-Seo Kil (1)
  Ah-Reum Han (1)
  Chong Hak Chae (2)
  Shi Yong Ryu (2)
  Eun-Kyoung Seo (1)
  
  1. Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea
  2. Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology, Daejeon, 305-600, Korea
  
• 刊物主题：Pharmacy; Pharmacology/Toxicology;
• 出版者：Springer Netherlands
• ISSN：1976-3786

文摘

Three new minor pyrrole alkaloids, 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1-methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate (3) were isolated from the fruits of Lycium chinense Miller (Solanaceae), along with the known compound, methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate (4). The structures of 1–4 were elucidated by analysis of their 1D- and 2D-NMR and HRMS data. The absolute configurations of 2–4, possessing a stereogenic center in each structure, were determined by comparison of their experimental electronic circular dichroism (ECD) with those of calculated ECD values.