A Microdosimetric Study of Electropulsation on Multiple Realistically Shaped Cells: Effect of Neighbours
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- 作者：Agnese Denzi ; Francesca Camera ; Caterina Merla…
- 关键词：Microdosimetry ; Mesodosimetry ; Electroporation ; Nanosecond and microsecond pulsed electric fields ; Shielding effect
- 刊名：Journal of Membrane Biology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：249
- 期：5
- 页码：691-701
- 全文大小：2,869 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Biochemistry
Human Physiology - 出版者：Springer New York
- ISSN：1432-1424
- 卷排序：249
文摘
Over the past decades, the effects of ultrashort-pulsed electric fields have been used to investigate their action in many medical applications (e.g. cancer, gene electrotransfer, drug delivery, electrofusion). Promising aspects of these pulses has led to several in vitro and in vivo experiments to clarify their action. Since the basic mechanisms of these pulses have not yet been fully clarified, scientific interest has focused on the development of numerical models at different levels of complexity: atomic (molecular dynamic simulations), microscopic (microdosimetry) and macroscopic (dosimetry). The aim of this work is to demonstrate that, in order to predict results at the cellular level, an accurate microdosimetry model is needed using a realistic cell shape, and with their position and packaging (cell density) characterised inside the medium.