Unklare Retinopathie nach intravitrealer Eingabe von Ocriplasmin

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• 作者：Dr. S. Abraham ; K. Wand ; S. Stumpfe ; N. Feucht ; C.P. Lohmann ; M. Maier
• 关键词：Vitreomakuläre Traktion ; Visusminderung ; Optische Kohärenztomographie ; Retina ; Gesichtsfeld ; Vitreomacular traction ; Visual loss ; Optical coherence tomography ; Retina ; Visual field
• 刊名：Der Ophthalmologe
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：113
• 期：2
• 页码：156-159
• 全文大小：710 KB
• 参考文献：1.Fahim AT, Khan NW, Johnson MW (2014) Acute panretinal structural and functional abnormalities after intravitreous ocriplasmin injection. JAMA Ophthalmol 132:484–486CrossRef PubMed
  2.Freund KB, Shah SA, Shah VP (2013) Correlation of transient vision loss with outer retinal disruption following intravitreal ocriplasmin. Eye 27:773–774PubMedCentral CrossRef PubMed
  3.JETREA (package insert) (2012) ThromboGenics Inc.: Iselin, NJ
  4.Singh RP, Li A, Bedi R et al (2013) Anatomical and visual outcomes following ocriplasmin treatment for symptomatic vitreomacular traction syndrome. Br J Ophthalmol. doi:10.1136/bjophthalmol -2013-304219 (Published Online First: [December 19, 2013])
  5.Stalmans P, Benz MS, Gandorfer A et al (2012) MIVI-TRUST study group. Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes. N Engl J Med 367:606–615CrossRef PubMed
  6.Steinle N, Quezada C, Nasir M et al (2014) Outer band reflectivity changes on SD-OCT following intravitreal ocriplasmin for vitreomacular traction (VMT) and macular holes (MH). ARVO 2014 annual meeting abstracts
  7.Tibbetts MD, Reichel E, Witkin AJ (2014) Vision loss after intravitreal ocriplasmin: correlation of spectral-domain optical coherence tomography and electroretinography. JAMA Ophthalmology 132:487–490CrossRef PubMed
  8.Warrow DJ, Lai MM, Patel A et al (2014) Treatment outcomes and spectral-domain opitcal coherence tomography findings of eyes with symptomatic vitreomacular adhesion treated with intravitreal ocriplasmin. Am J Ophthalmol. pii: S0002-9394(14)00579-0. doi:10.1016/j.ajo.2014.09.015
  
• 作者单位：Dr. S. Abraham (1)
  K. Wand (1)
  S. Stumpfe (1)
  N. Feucht (1)
  C.P. Lohmann (1)
  M. Maier (1)
  
  1. Klinik und Poliklinik für Augenheilkunde, Augenklinik, Klinikum rechts der Isar, Technische Universität München, Ismaningerstraße 22, 81675, München, Deutschland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Ophthalmology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-0423

文摘

Case report This article reports the case of a 50-year-old female patient who presented with reduced visual acuity of 0.8 p and metamorphopsia of the left eye caused by focal vitreomacular traction and who was treated with intravitreal Jetrea® (ocriplasmin). After injection the patient suffered from progressive nyctalopia and visual field defects. Electroretinography (ERG) showed decreased amplitudes and optical coherence tomography (OCT) showed decreased reflectivity in the ellipsoid layer that persisted for 2 months after treatment.