Anticancer drug sensitivity prediction in cell lines from baseline gene expression through recursive feature selection
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- 作者：Zuoli Dong ; Naiqian Zhang ; Chun Li ; Haiyun Wang ; Yun Fang ; Jun Wang…
- 关键词：Drug sensitivity prediction ; Feature selection ; Recursive feature elimination
- 刊名：BMC Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：15
- 期：1
- 全文大小：832 KB
- 刊物主题：Cancer Research; Oncology; Stem Cells; Animal Models; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2407
文摘
Background An enduring challenge in personalized medicine is to select right drug for individual patients. Testing drugs on patients in large clinical trials is one way to assess their efficacy and toxicity, but it is impractical to test hundreds of drugs currently under development. Therefore the preclinical prediction model is highly expected as it enables prediction of drug response to hundreds of cell lines in parallel.