Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach
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- 作者：Dimitrios Paraskevis (1) (2)
Oliver Pybus (3)
Gkikas Magiorkinis (2)
Angelos Hatzakis (2)
Annemarie MJ Wensing (4)
David A van de Vijver (5)
Jan Albert (6) (7)
Guiseppe Angarano (8)
Birgitta ?sj? (9)
Claudia Balotta (10)
Enzo Boeri (11)
Ricardo Camacho (12)
Marie-Laure Chaix (13)
Suzie Coughlan (14)
Dominique Costagliola (15)
Andrea De Luca (16)
Carmen de Mendoza (17)
Inge Derdelinckx (18)
Zehava Grossman (19)
Osama Hamouda (20)
IM Hoepelman (21)
Andrzej Horban (22)
Klaus Korn (23)
Claudia Kücherer (20)
Thomas Leitner (6) (7)
Clive Loveday (24)
Eilidh MacRae (25)
I Maljkovic-Berry (6) (7)
Laurence Meyer (25)
Claus Nielsen (26)
Eline LM Op de Coul (27)
Vidar Ormaasen (28)
Luc Perrin (29)
Elisabeth Puchhammer-St?ckl (30)
Lidia Ruiz (31)
Mika O Salminen (32)
Jean-Claude Schmit (33)
Rob Schuurman (4)
Vincent Soriano (17)
J Stanczak (22)
Maja Stanojevic (34)
Daniel Struck (33)
Kristel Van Laethem (1)
M Violin (10)
Sabine Yerly (29)
Maurizio Zazzi (35)
Charles A Boucher (4) (5)
Anne-Mieke Vandamme (1) - 刊名：Retrovirology
- 出版年：2009
- 出版时间：December 2009
- 年：2009
- 卷：6
- 期：1
- 全文大小：1264KB
- 参考文献：1. Peeters M, Honore C, Huet T, Bedjabaga L, Ossari S, Bussi P, Cooper RW, Delaporte E: Isolation and partial characterization of an HIV-related virus occurring naturally in chimpanzees in Gabon. / Aids 1989, 3: 625-30. CrossRef
2. Peeters M, Fransen K, Delaporte E, Van den Haesevelde M, Gershy-Damet GM, Kestens L, van der Groen G, Piot P: Isolation and characterization of a new chimpanzee lentivirus (simian immunodeficiency virus isolate cpz-ant) from a wild-captured chimpanzee. / Aids 1992, 6: 447-51. CrossRef
3. Gao F, Bailes E, Robertson DL, Chen Y, Rodenburg CM, Michael SF, Cummins LB, Arthur LO, Peeters M, Shaw GM, / et al.: Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. / Nature 1999, 397: 436-41. CrossRef
4. Hahn BH, Shaw GM, De Cock KM, Sharp PM: AIDS as a zoonosis: scientific and public health implications. / Science 2000, 287: 607-14. CrossRef
5. Sharp PM, Bailes E, Gao F, Beer BE, Hirsch VM, Hahn BH: Origins and evolution of AIDS viruses: estimating the time-scale. / Biochem Soc Trans 2000, 28: 275-82.
6. Heeney JL, Rutjens E, Verschoor EJ, Niphuis H, ten Haaft P, Rouse S, McClure H, Balla-Jhagjhoorsingh S, Bogers W, Salas M, / et al.: Transmission of simian immunodeficiency virus SIVcpz and the evolution of infection in the presence and absence of concurrent human immunodeficiency virus type 1 infection in chimpanzees. / J Virol 2006, 80: 7208-218. CrossRef
7. Gilbert MT, Rambaut A, Wlasiuk G, Spira TJ, Pitchenik AE, Worobey M: The emergence of HIV/AIDS in the Americas and beyond. / Proc Natl Acad Sci USA 2007, 104: 18566-8570. CrossRef
8. Robbins KE, Lemey P, Pybus OG, Jaffe HW, Youngpairoj AS, Brown TM, Salemi M, Vandamme AM, Kalish ML: U.S. Human immunodeficiency virus type 1 epidemic: date of origin, population history, and characterization of early strains. / J Virol 2003, 77: 6359-366. CrossRef
9. Brunet JB, Bouvet E, Massari V: Epidemiological aspects of acquired immune deficiency syndrome in France. / Ann N Y Acad Sci 1984, 437: 334-39. CrossRef
10. Glauser MP, Francioli P: Clinical and epidemiological survey of acquired immune deficiency syndrome in Europe. / Eur J Clin Microbiol 1984, 3: 55-8. CrossRef
11. Melbye M, Biggar RJ, Ebbesen P, Sarngadharan MG, Weiss SH, Gallo RC, Blattner WA: Seroepidemiology of HTLV-III antibody in Danish homosexual men: prevalence, transmission, and disease outcome. / Br Med J (Clin Res Ed) 1984, 289: 573-75. CrossRef
12. Casado C, Urtasun I, Saragosti S, Chaix ML, de Rossi A, Cattelan AM, Dietrich U, Lopez-Galindez C: Different distribution of HIV type 1 genetic variants in European patients with distinct risk practices. / AIDS Res Hum Retroviruses 2000, 16: 299-04. CrossRef
13. Lukashov VV, Kuiken CL, Vlahov D, Coutinho RA, Goudsmit J: Evidence for HIV type 1 strains of U.S. intravenous drug users as founders of AIDS epidemic among intravenous drug users in northern Europe. / AIDS Res Hum Retroviruses 1996, 12: 1179-183. CrossRef
14. Clumeck N, Sonnet J, Taelman H, Mascart-Lemone F, De Bruyere M, Vandeperre P, Dasnoy J, Marcelis L, Lamy M, Jonas C, / et al.: Acquired immunodeficiency syndrome in African patients. / N Engl J Med 1984, 310: 492-97. CrossRef
15. Vittecoq D, May T, Roue RT, Stern M, Mayaud C, Chavanet P, Borsa F, Jeantils P, Armengaud M, Modai J, / et al.: Acquired immunodeficiency syndrome after travelling in Africa: an epidemiological study in seventeen Caucasian patients. / Lancet 1987, 1: 612-15. CrossRef
16. Chaix ML, Descamps D, Harzic M, Schneider V, Deveau C, Tamalet C, Pellegrin I, Izopet J, Ruffault A, Masquelier B, / et al.: Stable prevalence of genotypic drug resistance mutations but increase in non-B virus among patients with primary HIV-1 infection in France. / Aids 2003, 17: 2635-643. CrossRef
17. Descamps D, Chaix ML, Andre P, Brodard V, Cottalorda J, Deveau C, Harzic M, Ingrand D, Izopet J, Kohli E, / et al.: French national sentinel survey of antiretroviral drug resistance in patients with HIV-1 primary infection and in antiretroviral-naive chronically infected patients in 2001-002. / J Acquir Immune Defic Syndr 2005, 38: 545-52. CrossRef
18. Deroo S, Robert I, Fontaine E, Lambert C, Plesseria JM, Arendt V, Staub T, Hemmer R, Schneider F, Schmit JC: HIV-1 subtypes in Luxembourg, 1983-000. / Aids 2002, 16: 2461-467. CrossRef
19. Machuca R, Bogh M, Salminen M, Gerstoft J, Kvinesdal B, Pedersen C, Obel N, Nielsen H, Nielsen C: HIV-1 subtypes in Denmark. / Scand J Infect Dis 2001, 33: 697-01. CrossRef
20. Sonnerborg A, Durdevic S, Giesecke J, Sallberg M: Dynamics of the HIV-1 subtype distribution in the Swedish HIV-1 epidemic during the period 1980 to 1993. / AIDS Res Hum Retroviruses 1997, 13: 343-45. CrossRef
21. Snoeck J, Van Laethem K, Hermans P, Van Wijngaerden E, Derdelinckx I, Schrooten Y, Vijver DA, De Wit S, Clumeck N, Vandamme AM: Rising prevalence of HIV-1 non-B subtypes in Belgium: 1983-001. / J Acquir Immune Defic Syndr 2004, 35: 279-85. CrossRef
22. Lospitao E, Alvarez A, Soriano V, Holguin A: HIV-1 subtypes in Spain: a retrospective analysis from 1995 to 2003. / HIV Med 2005, 6: 313-20. CrossRef
23. Boni J, Pyra H, Gebhardt M, Perrin L, Burgisser P, Matter L, Fierz W, Erb P, Piffaretti JC, Minder E, / et al.: High frequency of non-B subtypes in newly diagnosed HIV-1 infections in Switzerland. / J Acquir Immune Defic Syndr 1999, 22: 174-79.
24. Op de Coul EL, Coutinho RA, van der Schoot A, van Doornum GJ, Lukashov VV, Goudsmit J, Cornelissen M: The impact of immigration on env HIV-1 subtype distribution among heterosexuals in the Netherlands: influx of subtype B and non-B strains. / Aids 2001, 15: 2277-286. CrossRef
25. Paraskevis D, Magiorkinis E, Magiorkinis G, Sypsa V, Paparizos V, Lazanas M, Gargalianos P, Antoniadou A, Panos G, Chrysos G, / et al.: Increasing prevalence of HIV-1 subtype A in Greece: estimating epidemic history and origin. / J Infect Dis 2007, 196: 1167-176. CrossRef
26. Bobkov A, Kazennova E, Selimova L, Bobkova M, Khanina T, Ladnaya N, Kravchenko A, Pokrovsky V, Cheingsong-Popov R, Weber J: A sudden epidemic of HIV type 1 among injecting drug users in the former Soviet Union: identification of subtype A, subtype B, and novel gagA/envB recombinants. / AIDS Res Hum Retroviruses 1998, 14: 669-76. CrossRef
27. Holmes EC, Zhang LQ, Robertson P, Cleland A, Harvey E, Simmonds P, Leigh Brown AJ: The molecular epidemiology of human immunodeficiency virus type 1 in Edinburgh. / J Infect Dis 1995, 171: 45-3.
28. Brown AJ, Lobidel D, Wade CM, Rebus S, Phillips AN, Brettle RP, France AJ, Leen CS, McMenamin J, McMillan A, / et al.: The molecular epidemiology of human immunodeficiency virus type 1 in six cities in Britain and Ireland. / Virology 1997, 235: 166-77. CrossRef
29. Thomson MM, Najera R: Travel and the introduction of human immunodeficiency virus type 1 non-B subtype genetic forms into Western countries. / Clin Infect Dis 2001, 32: 1732-737. CrossRef
30. Liitsola K, Holmstrom P, Laukkanen T, Brummer-Korvenkontio H, Leinikki P, Salminen MO: Analysis of HIV-1 genetic subtypes in Finland reveals good correlation between molecular and epidemiological data. / Scand J Infect Dis 2000, 32: 475-80. CrossRef
31. Palma AC, Araujo F, Duque V, Borges F, Paixao MT, Camacho R: Molecular epidemiology and prevalence of drug resistance-associated mutations in newly diagnosed HIV-1 patients in Portugal. / Infect Genet Evol 2007, 7: 391-98. CrossRef
32. Paraskevis D, Wensing AMJ, Vercauteren J, Vijver DA, Albert J, Asjo B, on behalf of the SPREAD-programme, / et al.: Prevalence of HIV-1 subtypes among newly HIV-1 diagnosed individuals during 2002-003 in Europe: Evidence for a continuous introduction of non-B subtypes. / 1st International Workshop on HIV Transmission; Toronto, Canada 2006, 31. Abstract No 34
33. Abecasis A, Wensing A, Paraskevis D, Vercauteuren D, Vijver D, Albert J, / et al.: obotS-p Demographic determinants of HIV-1 subtype in Europe. / Sixth European HIV Drug Resistance Workshop; Budapest, Hungary 2008.
34. Drummond AJ, Pybus OG, Rambaut A, Forsberg R, Rodrigo A: Measurably evolving populations. / TRENDS in Ecology and Evolution 2003, 18: 481-88. CrossRef
35. Coffin JM: HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. / Science 1995, 267: 483-89. CrossRef
36. Leitner T, Escanilla D, Franzen C, Uhlen M, Albert J: Accurate reconstruction of a known HIV-1 transmission history by phylogenetic tree analysis. / Proc Natl Acad Sci USA 1996, 93: 10864-0869. CrossRef
37. Wallace RG, Hodac H, Lathrop RH, Fitch WM: A statistical phylogeography of influenza A H5N1. / Proc Natl Acad Sci USA 2007, 104: 4473-478. CrossRef
38. Holmes EC: Evolutionary history and phylogeography of human viruses. / Annu Rev Microbiol 2008, 62: 307-28. CrossRef
39. Nakano T, Lu L, Liu P, Pybus OG: Viral gene sequences reveal the variable history of hepatitis C virus infection among countries. / J Infect Dis 2004, 190: 1098-108. CrossRef
40. Slatkin M, Maddison WP: A cladistic measure of gene flow inferred from the phylogenies of alleles. / Genetics 1989, 123: 603-13.
41. Fitch WM: Toward defining the course of evolution: Minimal change for a specific tree topology. / Syst Zool 1971, 20: 406-16. CrossRef
42. Lukashov VV, Karamov EV, Eremin VF, Titov LP, Goudsmit J: Extreme founder effect in an HIV type 1 subtype A epidemic among drug users in Svetlogorsk, Belarus. / AIDS Res Hum Retroviruses 1998, 14: 1299-303. CrossRef
43. Liitsola K, Tashkinova I, Laukkanen T, Korovina G, Smolskaja T, Momot O, Mashkilleyson N, Chaplinskas S, Brummer-Korvenkontio H, Vanhatalo J, / et al.: HIV-1 genetic subtype A/B recombinant strain causing an explosive epidemic in injecting drug users in Kaliningrad. / AIDS 1998, 12: 1907-919. CrossRef
44. Nabatov AA, Kravchenko ON, Lyulchuk MG, Shcherbinskaya AM, Lukashov VV: Simultaneous introduction of HIV type 1 subtype A and B viruses into injecting drug users in southern Ukraine at the beginning of the epidemic in the former Soviet Union. / AIDS Res Hum Retroviruses 2002, 18: 891-95. CrossRef
45. Bobkov A, Cheingsong-Popov R, Selimova L, Ladnaya N, Kazennova E, Kravchenko A, Fedotov E, Saukhat S, Zverev S, Pokrovsky V, Weber J: An HIV type 1 epidemic among injecting drug users in the former Soviet Union caused by a homogeneous subtype A strain. / AIDS Res Hum Retroviruses 1997, 13: 1195-201. CrossRef
46. Brenner BG, Roger M, Routy JP, Moisi D, Ntemgwa M, Matte C, Baril JG, Thomas R, Rouleau D, Bruneau J, / et al.: High rates of forward transmission events after acute/early HIV-1 infection. / J Infect Dis 2007, 195: 951-59. CrossRef
47. Lewis F, Hughes GJ, Rambaut A, Pozniak A, Leigh Brown AJ: Episodic sexual transmission of HIV revealed by molecular phylodynamics. / PLoS Med 2008, 5: e50. CrossRef
48. Gifford RJ, de Oliveira T, Rambaut A, Pybus OG, Dunn D, Vandamme AM, Kellam P, Pillay D: Phylogenetic surveillance of viral genetic diversity and the evolving molecular epidemiology of human immunodeficiency virus type 1. / J Virol 2007, 81: 13050-3056. CrossRef
49. Hue S, Pillay D, Clewley JP, Pybus OG: Genetic analysis reveals the complex structure of HIV-1 transmission within defined risk groups. / Proc Natl Acad Sci USA 2005, 102: 4425-429. CrossRef
50. Paraskevis D, Zavitsanou M, Magiorkinis E, Papa A, Magiorkinis G, Beloukas A, Sypsa V, Nikolopoulos G, Malisiovas N, Hatzakis A: Molecular typing of the subtype B transmission networks: a nationwide study to estimate the contact patterns of the HIV epidemic in Greece. / 16th Conference on Retroviruses and Opportunistic Infections. Montreal, Canada 2009.
51. Op de Coul EL, Prins M, Cornelissen M, Schoot A, Boufassa F, Brettle RP, Hernandez-Aguado L, Schiffer V, McMenamin J, Rezza G, / et al.: Using phylogenetic analysis to trace HIV-1 migration among western European injecting drug users seroconverting from 1984 to 1997. / AIDS 2001, 15: 257-66. CrossRef
52. Skar H, Sylvan S, Hansson HB, Gustavsson O, Boman H, Albert J, Leitner T: Multiple HIV-1 introductions into the Swedish intravenous drug user population. / Infect Genet Evol 2008, 8: 545-52. CrossRef
53. Wensing AMJ, Vercauteren J, Vijver DA, Albert J, Asjo B, Balotta C, Camacho R, Coughlan S, Grossman Z, Horban A, / et al.: Transmission of drug-resistant HIV-1 in Europe remains limited to single classes. / Aids 2008, 22: 625-35. CrossRef
54. Hue S, Clewley JP, Cane PA, Pillay D: Investigation of HIV-1 transmission events by phylogenetic methods: requirement for scientific rigour. / Aids 2005, 19: 449-50. CrossRef
55. Lemey P, Derdelinckx I, Rambaut A, Van Laethem K, Dumont S, Vermeulen S, Van Wijngaerden E, Vandamme AM: Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain. / J Virol 2005, 79: 11981-1989. CrossRef
56. Paraskevis D, Magiorkinis E, Magiorkinis G, Kiosses VG, Lemey P, Vandamme AM, Rambaut A, Hatzakis A: Phylogenetic reconstruction of a known HIV-1 CRF04_cpx transmission network using maximum likelihood and Bayesian methods. / J Mol Evol 2004, 59: 709-17. CrossRef
57. Wensing AM, Vijver DA, Angarano G, Asjo B, Balotta C, Boeri E, Camacho R, Chaix ML, Costagliola D, De Luca A, / et al.: Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management. / J Infect Dis 2005, 192: 958-66. CrossRef
58. Thompson JD, Higgins DG, Gibson TJ: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. / Nucleic Acids Res 1994, 22: 4673-680. CrossRef
59. Stamatakis A, Hoover P, Rougemont J: A rapid bootstrap algorithm for the RAxML Web servers. / Syst Biol 2008, 57: 758-71. CrossRef
60. Maddison WP, Maddison DR: MacClade: analysis of phylogeny and character evolution. / 4 Edition Sunderland, Mass: Sinaeur Associates 2003.
61. Sankoff D, Cedergren RJ: Simultaneous comparison of three or more sequences related by a tree. / Time Warps, String Edits, and Macromolecules: The Theory and Practice of Sequence Comparison / (Edited by: Sankoff D, Kruskal JB). Reading, Mass: Addison-Wesley 1983, 253-63.
62. Rinsma I, Hendy M, Penny D: Minimally colored trees. / Math Biosci 1990, 98: 201-10. CrossRef
63. Maddison WP, Maddison DR: Mesquite: a modular system for evolutionary analysis. Version 2.6. 2009. - 作者单位：Dimitrios Paraskevis (1) (2)
Oliver Pybus (3)
Gkikas Magiorkinis (2)
Angelos Hatzakis (2)
Annemarie MJ Wensing (4)
David A van de Vijver (5)
Jan Albert (6) (7)
Guiseppe Angarano (8)
Birgitta ?sj? (9)
Claudia Balotta (10)
Enzo Boeri (11)
Ricardo Camacho (12)
Marie-Laure Chaix (13)
Suzie Coughlan (14)
Dominique Costagliola (15)
Andrea De Luca (16)
Carmen de Mendoza (17)
Inge Derdelinckx (18)
Zehava Grossman (19)
Osama Hamouda (20)
IM Hoepelman (21)
Andrzej Horban (22)
Klaus Korn (23)
Claudia Kücherer (20)
Thomas Leitner (6) (7)
Clive Loveday (24)
Eilidh MacRae (25)
I Maljkovic-Berry (6) (7)
Laurence Meyer (25)
Claus Nielsen (26)
Eline LM Op de Coul (27)
Vidar Ormaasen (28)
Luc Perrin (29)
Elisabeth Puchhammer-St?ckl (30)
Lidia Ruiz (31)
Mika O Salminen (32)
Jean-Claude Schmit (33)
Rob Schuurman (4)
Vincent Soriano (17)
J Stanczak (22)
Maja Stanojevic (34)
Daniel Struck (33)
Kristel Van Laethem (1)
M Violin (10)
Sabine Yerly (29)
Maurizio Zazzi (35)
Charles A Boucher (4) (5)
Anne-Mieke Vandamme (1)
1. Rega Institute for Medical research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B-3000, Leuven, Belgium
2. National Retrovirus Reference Center, Department of Hygiene Epidemiology and Medical Statistics, Medical School, University of Athens, M. Asias 75, GR-11527, Athens, Greece
3. Department of Zoology, University of Oxford, South Parks Road, OX1 3PS, Oxford, UK
4. University Medical Center Utrecht, Department of Virology, G04.614, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
5. Department of Virology, Erasmus MC, University Medical Centre, Postbus 2040, 3000 CA, Rotterdam, The Netherlands
6. Department of Microbiology, Tumor and Cellbiology, Karolinska Institutet, SE 171 77, Stockholm, Sweden
7. Dept of Virology, Swedish Institute for Infectious Disease Control, SE-171 82, Solna, Sweden
8. Clinic of Infectious Diseases, University of Foggia, Ospedali Riuniti -Via L. Pinto, 71100, Foggia, Italy
9. Center for Research in Virology, University of Bergen, Bergen High Technology Center, N-5020, Bergen, Norway
10. Institute of Infectious and Tropical Diseases, University of Milano, Via Festa del Perdono 7, 20122, Milano, Italy
11. Diagnostica and Ricerca San Raffaele, Centro San Luigi, I.R.C.C.S. Istituto Scientifico San Raffaele, Milan, Italy
12. Laboratorio de Virologia, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-008, Lisboa, Portugal
13. EA 3620, Universite Paris Descartes Virologie, CHU Necker, Paris, France
14. National Virus Reference Laboratory, University College, Dublin, Ireland
15. INSERM U263 et SC4, Faculté de médecine Saint-Antoine, Université Pierre et Marie Curie, 27 rue de Chaligny, F-75571, Paris, France
16. Department of Infectious Diseases, Catholic University, L.go A. Gemelli, 8 00168, Rome, Italy
17. Hospital Carlos III, Hospital Carlos III, Madrid, Spain
18. Internal Medicine, UZ Leuven, Belgium
19. National. HIV Reference Lab, Central Virology, Public Health Laboratories, MOH Central Virology, Sheba Medical Center, 2 Ben-Tabai Street, Israel
20. Robert Koch Institut (RKI), Nordufer 20, 13353, Berlin, Germany
21. Department of Internal Medicine and Infectious Diseases F02.126, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
22. Hospital for Infectious Diseases, Center for Diagnosis & Therapy Warsaw 37, Wolska Str, 01-201, Warszawa, Poland
23. University of Erlangen, Schlossplatz 4, D-91054, Erlangen, Germany
24. ICVC Charity Laboratories, 3d floor, Apollo Centre Desborough Road High Wycombe, HP11 2QW, Buckinghamshire, UK
25. Inserm, Le Kremlin-Bicêtre, F-94276, France
26. Statens Serum Institut Copenhagen, 5, Artillerivej, 2300, Copenhagen, Denmark
27. Centre for Infectious Disease Control (Epidemiology & Surveillance), National Institute for Public Health and the Environment (RIVM), 3720 BA, Bilthoven, The Netherlands
28. Department of Infectious Diseases, Ullevaal University Hospital, Kirkeveien 166, N-0407, Oslo, Norway
29. Laboratory of Virology, Geneva University Hospital and University of Geneva Medical School, Geneva, Switzerland
30. Institute of Virology, Medical University Vienna, Kinderspitalgasse 15, Vienna, Austria
31. IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Ctra. de Canyet s/n, 08916, Badalona (Barcelona), Spain
32. HIV laboratory and department of infectious disease epidemiology, National Public Health Institute, Mannerheimintie 166, FIN-00300, Helsinki, Finland
33. Retrovirology Laboratory, National service of Infectious Diseases, Centre Hospitalier de Luxembourg, 4 Rue Barblé, L-1210, Luxembourg
34. Institute of Microbiology and Immunology Virology Department, University of Belgrade School of Medicine, Dr Subotica 1, 11000, Belgrade, Serbia
35. Section of Microbiology, Department of Molecular Biology, University of Siena, Italy - ISSN：1742-4690
文摘
Background The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced. Results In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferred from viral phylogenies by character reconstruction using parsimony. With regard to the spatial dispersal of the HIV subtype B sequences across viral phylogenies, in most of the countries in Europe the epidemic was introduced by multiple sources and subsequently spread within local networks. Poland provides an exception where most of the infections were the result of a single point introduction. According to the significant migratory pathways, we show that there are considerable differences across Europe. Specifically, Greece, Portugal, Serbia and Spain, provide sources shedding HIV-1; Austria, Belgium and Luxembourg, on the other hand, are migratory targets, while for Denmark, Germany, Italy, Israel, Norway, the Netherlands, Sweden, Switzerland and the UK we inferred significant bidirectional migration. For Poland no significant migratory pathways were inferred. Conclusion Subtype B phylogeographies provide a new insight about the geographical distribution of viral lineages, as well as the significant pathways of virus dispersal across Europe, suggesting that intervention strategies should also address tourists, travellers and migrants.