Antenatal screening for HIV, hepatitis B and syphilis in the Netherlands is effective

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• 作者：Eline LM Op de Coul (1)
  Susan Hahné (1)
  Yolanda WM van Weert (1)
  Petra Oomen (1)
  Colette Smit (2)
  Kitty PB van der Ploeg (3)
  Daan W Notermans (4)
  Kees Boer (5)
  Marianne AB van der Sande (1)
  
• 刊名：BMC Infectious Diseases
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：11
• 期：1
• 全文大小：279KB
• 参考文献：1. Op de Coul EL, van Weert JW, Oomen PJ, Smit C, Hahné SJ, Notermans DW, Van der Sande MA: Prenatale screening op hiv, hepatitis B en syphilis in Nederland effectief [article in Dutch]. / Ned Tijdschr Geneeskd 2010, 154:A2175.
  2. RIVM: [derzoek" class="a-plus-plus">http://www.rivm.nl/pns/downloads/bloedonderzoek] / Protocol antenatal screening infectious diseases and erthrocytes immunisation [In Dutch: Draaiboek prenatale screening infectieziekten en erytrocytenimmunisatie]. Version 2.0. RIVM - Center for Population research. Bilthoven; 2008.
  3. Boer K, Nellen JF, Kreyenbroek ME, Godfried MH: Treatment of HIV-infected pregnant women: prevention of virus transmission and adverse effects in mother and child [Article in Dutch]. / Ned Tijdschr geneeskd 2009, 153:B410.
  4. Ploeg , CPB van der, Toll DB, Oomen P, Op de Coul ELM, Hahné SJM: [http://www.rivm.nl/pns/Images/2008.036%20TNO%20rapport%20Procesmonitoring%20PSIE%202005-007_tcm95-0636.pdf] / Procesmonitoring antenatal screening infectious diseases and erythrocytes immunisation 2005-007 [in Dutch: Procesmonitoring prenatale screening infectieziekten en erythrocytenimmunisatie 2005-007. TNO quality of life. Leiden; 2009.
  5. Ploeg , CPB van der, / et al.: [http://www.ncvgz.nl] / Participation in prenatal screening for infectious diseases and erythrocytes immunisation in pregant women from risk countries [in Dutch: Deelname aan de Prenatale Screening op Infectieziekten en Erythrocytenimmunisatie bij zwangeren uit risicolanden. poster NCVGZ, Nederlands congres volksgezondheid; 2010.
  6. Van der Kemp SA, Hollander ML, Van Vree FM: [def.PDF" class="a-plus-plus">http://www.research.nl/files/rvb/reportcenter/Rapporten/B3053/B3053eindrapdef.PDF] / 'Bloedonderzoek in beeld: een evaluatie van de prenatale screening op hiv en lues' [in Dutch]. Leiden: Research for Policy: Report B3053/B3054; 2006.
  7. Gras L, Sighem van AI, Smit C, Zaheri S, Stolte I, Schuitemaker H, Wolf de F: / Monitoring of human immunodeficiency virus (HIV) infection in the Netherlands. Report 2009. Amsterdam: Stichting HIV Monitoring; 2010.
  8. Hahné SJM, Zomer T, Heiningen van FM, Boot H, Holty L, Abbink F, Melker de HE: [http://www.rivm.nl] / Evaluation Evaluatie preventie perinatale HBV transmissie. RIVM rapport 210031002/2008. Bilthoven: RIVM; 2008.
  9. Boot HJ, Hahné S, Cremer J, Wong A, Boland G, Van Loon AM: Persistent and transient hepatitis B virus (HBV) infections in children born to HBV-infected mothers despite active and passive vaccination. / J Viral Hepat 2010,17(12):872-. CrossRef
  10. Herremans M, Notermans DW, Mommers M, Kortbeek LM: Comparison of a treponema pallidum IgM immunoblot with a 19S fluorescent treponemal antibody absorption test for the diagnosis of congenital syphilis. / Diagn Microbiol Infect Dis 2007, 59:61-. CrossRef
  11. Fiumara NJ, Fleming WL, Downing JG, Good FL: The incidence of prenatal syphilis at the Boston City Hospital. / N Engl J Med 1952, 247:48-2. CrossRef
  12. Bont J, Cairo I, van Doornum GJJ, Coutinho RA, Bleker OP: Positive results from serologic screening for syphilis in pregnancy in the Amsterdam region, 1991-995 [article in Dutch]. / Ned Tijdschr Geneeskd 1999, 143:2312-.
  13. Deblonde J, Claeys P, Temmerman M: Antenatal HIV screening in Europe: a review of policies. / Eur J Public Health 2007,17(5):414-. CrossRef
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  15. Health council of the Netherlands: [http://www.gezondheidsraad.nl] / Standing committee on infectious diseases and immunology. Reconsidering the policy on HIV testing [in Dutch: Herziening van het HIV-testbeleid]. Publication no 1999/02. The Hague: Health Council of the Netherlands; 1999.
  16. Omata M, Ehata T, Yokosuka O, Hososa K, Ohto M: Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. / N Engl J Med 1991, 324:1699-704. CrossRef
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  18. Van der Ploeg CPB, van den Akker ME, Sleuven BE: / Kwaliteit van het informatiesysteem voor de prenatale screening infectieziekten en erythrocytenimmunisatie (PSIE), 2008. TNO-rapport KvL/P&Z/2008.035. Leiden: TNO; 2008.
  19. Postma MJ, van den Hoek JAR, Beck EJ, Heeg B, Jager JC, Coutinho RA: Pharmaco-economic evaluation of universal HIV-screening in pregnancy; a cost-efficacy analysis in Amsterdam [article in Dutch]. / Ned Tijdschr Geneeskd 2000,144(16):749-4.
  20. Rozenbaum MH, Verweel G, Folkerts DK, Dronkers F, van den Hoek JA, Hartwig NG, de Groot R, Postma MJ: Cost-effectiveness estimates for antenatal HIV testing in the Netherlands. / Int J STD AIDS 2008, 19:668-5. CrossRef
  21. Struijs JN, de Wit GA, Jager JC: / Literatuuronderzoek naar kosteneffectiviteitsaspecten van de screening van zwangeren op syfilis ter preventie van congenitale syfilis. Rapport 403505007. Bilthoven: RIVM; 2002.
  22. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/11/185/prepub
  
• 作者单位：Eline LM Op de Coul (1)
  Susan Hahné (1)
  Yolanda WM van Weert (1)
  Petra Oomen (1)
  Colette Smit (2)
  Kitty PB van der Ploeg (3)
  Daan W Notermans (4)
  Kees Boer (5)
  Marianne AB van der Sande (1)
  
  1. Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands
  2. Stichting HIV Monitoring, Academic Medical Centre of the University of Amsterdam, Amsterdam, Netherlands
  3. department of Prevention and Healthcare, TNO quality of life, Leiden, Netherlands
  4. Laboratory of Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, Netherlands
  5. Academic Medical Centre, department of gynaecology, University of Amsterdam, Amsterdam, Netherlands
  

文摘

Background A screening programme for pregnant women has been in place since the 1950s in the Netherlands. In 2004 universal HIV screening according to opting out was implemented. Here, we describe the evaluation of the effectiveness of antenatal screening in the Netherlands for 2006-2008 for HIV, hepatitis B virus (HBV) and syphilis in preventing mother-to-child transmission, by using various data sources. Methods The results of antenatal screening (2006-2008) were compared with data from pregnant women and newborns from other data sources. Results Each year, around 185,000 pregnant women were screened for HIV, HBV and syphilis. Refusal rates for the screening tests were low, and were highest (0.2%) for HIV. The estimated annual prevalence of HIV among pregnant women was 0.05%. Prior to the introduction of screening, 5-10 children were born with HIV annually After the introduction of screening in 2004, only 4 children were born with HIV (an average of 1 per year). Two of these mothers had become pregnant prior to 2004; the third mother was HIV negative at screening and probably became infected after screening; the fourth mother's background was unknown. Congenital syphilis was diagnosed in fewer than 5 newborns annually and 5 children were infected with HBV. In 3 of these, the mothers were HBeAg positive (a marker for high infectivity). We estimated that 5-10 HIV, 50-75 HBV and 10 syphilis cases in newborns had been prevented annually as a result of screening. Conclusions The screening programme was effective in detecting HIV, HBV and syphilis in pregnant women and in preventing transmission to the child. Since the introduction of the HIV screening the number of children born with HIV has fallen dramatically. Previous publication [Translation from: 'Prenatale screening op hiv, hepatitis B en syphilis in Nederland effectief', published in 'The Dutch Journal of Medicine ' (NTVG, in Dutch)]