Difference between random and imprinted X inactivation in common voles

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• 作者：Elena V. Dementyeva ; Alexander I. Shevchenko ; Olga V. Anopriyenko ; Nina A. Mazurok ; Eugeny A. Elisaphenko ; Tatyana B. Nesterova ; Neil Brockdorff and Suren M. Zakian
• 刊名：Chromosoma
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：119
• 期：5
• 页码：541-552
• 全文大小：492.1 KB

文摘

During early development in female mammals, most genes on one of the two X-chromosomes undergo transcriptional silencing. In the extraembryonic lineages of some eutherian species, imprinted X-inactivation of the paternal X-chromosome occurs. In the cells of the embryo proper, the choice of the future inactive X-chromosome is random. We mapped several genes on the X-chromosomes of five common vole species and compared their expression and methylation patterns in somatic and extraembryonic tissues, where random and imprinted X-inactivation occurs, respectively. In extraembryonic tissues, more genes were expressed on the inactive X-chromosome than in somatic tissues. We also found that the methylation status of the X-linked genes was always in accordance with their expression pattern in somatic, but not in extraembryonic tissues. The data provide new evidence that imprinted X-inactivation is less complete and/or stable than the random form and DNA methylation contributes less to its maintenance.