Lymphocyte function following radium-223 therapy in patients with metastasized, castration-resistant prostate cancer
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- 作者：Vahé Barsegian ; Stefan P. Müller…
- 关键词：Radium ; 223 therapy ; Antimicrobial immune response ; Lymphocyte proliferation ; ELISpot ; Cytokine
- 刊名：European Journal of Nuclear Medicine and Molecular Imaging
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：44
- 期：2
- 页码：242-246
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1619-7089
- 卷排序：44
文摘
PurposeTherapy with the alpha-emitter radium-223 chloride (223Ra) is an innovative therapeutic option in patients with metastasized, castration-resistant prostate cancer. However, radiotherapy can lead to hematopoietic toxicity. The aim of this study was to determine if 223Ra therapy induces an impairment of cellular antimicrobial immune responses.