Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome

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• 作者：Elizabeth H Aitken (1)
  Elnara M Negri (2)
  Renato Barboza (3)
  Maria RI Lima (1)
  Jos茅 M 脕lvarez (1)
  Claudio RF Marinho (4)
  Elia G Caldini (2)
  Sabrina Epiphanio (1) (5)
  
  1. Department of Immunology ; University of S茫o Paulo ; S茫o Paulo ; Brazil
  2. Laboratory of Medical Investigation 59 ; Faculty of Medicine ; University of S茫o Paulo ; S茫o Paulo ; Brazil
  3. Department of Physical and Earth Sciences ; Federal University of S茫o Paulo ; Diadema ; Brasil
  4. Department of Parasitology ; University of S茫o Paulo ; S茫o Paulo ; Brazil
  5. Department of Clinical and Toxicological Analyses ; Faculty of Pharmaceutical Sciences ; University of S茫o Paulo ; S茫o Paulo ; Brazil
  
• 关键词：Malaria ; Plasmodium ; Acute lung injury (ALI) ; Acute respiratory distress syndrome (ARDS) ; Transmission electron microscopy ; Murine model
• 刊名：Malaria Journal
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：13
• 期：1
• 全文大小：1,535 KB
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• 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine;
• 出版者：BioMed Central
• ISSN：1475-2875

文摘

Background The mechanisms through which infection with Plasmodium spp. result in lung disease are largely unknown. Recently a number of mouse models have been developed to research malaria-associated lung injury but no detailed ultrastructure studies of the disease in its terminal stages in a murine model have yet been published. The goal was to perform an ultrastructural analysis of the lungs of mice that died with malaria-associated acute lung injury/acute respiratory distress syndrome to better determine the relevancy of the murine models and investigate the mechanism of disease. Methods DBA/2 mice were infected with Plasmodium berghei strain ANKA. Mice had their lungs removed immediately after death, processed using standard methods and viewed by transmission electron microscopy (TEM). Results Infected red blood cell:endothelium contact, swollen endothelium with distended cytoplasmic extensions and thickening of endothelium basement membrane were observed. Septa were thick and filled with congested capillaries and leukocytes and the alveolar spaces contained blood cells, oedema and cell debris. Conclusion Results show that the lung ultrastructure of P. berghei ANKA-infected mice has similar features to what has been described in post-mortem TEM studies of lungs from individuals infected with Plasmodium falciparum. These data support the use of murine models to study malaria-associated acute lung injury.