Synthesis and crystal structures of two novel 3,4,5- trimethoxyphenyl derivatives from (Z)-1-[(2?3?dinitro-4?methoxy)-phenyl]-2-[(3?4?5?trimethoxy)-phenyl]?ethene

详细信息    查看全文

• 作者：Maria G. Miranda ; Elizabeth J. Norton ; Rodney P. Feazell ; Kevin K. Klausmeyer and Kevin G. Pinney
• 关键词：KEY WORDS ; combretastatin ; tubulin ; stilbene ; bi ; aryl
• 刊名：Journal of Chemical Crystallography
• 出版年：2006
• 出版时间：May, 2006
• 年：2006
• 卷：36
• 期：5
• 页码：309-314
• 全文大小：790 KB

文摘

The title compounds, (Z)-1-[(2′,4′-dimethoxy-3′-nitro)-phenyl]-2-[(3″,4″,5″-trimethoxy)-phenyl]ethene, C₁₉H₂₁O₇N (I), and 2-amino-4-methyl-6-(3,4,5-trimethoxy-phenyl)-pyrimidine, C₁₄H₁₇O₃N₃ (II), were obtained unexpectedly from a reaction involving (Z)-1-[(2′,3′-dinitro-4′-methoxy)-phenyl]-2-[(3″,4″,5″-trimethoxy)-phenyl]ethene (IV). The molecular structures of these compounds were obtained by single-crystal X-ray diffraction. Crystallization of I occurs in the centrosymmetric monoclinic space group P2₁/c (No. 14) with a=7.7311(5), b=19.9239(13), c=11.5725(8); and β=92.193(3) and Z=4. Crystallization of II occurs in the centrosymmetric monoclinic space group C2/c (No. 15) with a=21.296(2), b=6.8963(7), c=20.001(2); and β=114.121(6) and Z=8. Details of the synthesis and the structural characterization of the title compounds are presented and discussed.