Developmental remodeling of relay cells in the dorsal lateral geniculate nucleus in the absence of retinal input
详细信息 查看全文
- 作者：Rana N. El-Danaf ; Thomas E. Krahe ; Emily K. Dilger…
- 关键词：Dorsal lateral geniculate nucleus ; Retinogeniculate pathway ; Relay cells ; Retinal ganglion cells ; Dendritic development ; math5 null
- 刊名：Neural Development
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：10
- 期：1
- 全文大小：2,990 KB
- 刊物主题：Neurosciences; Developmental Biology;
- 出版者：BioMed Central
- ISSN：1749-8104
文摘
Background The dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been the primary focus, however much less is known about the maturation of their synaptic targets, the relay cells of the dLGN. Here we examined the growth and maturation of relay cells during the first few weeks of life and addressed whether early retinal innervation affects their development. To accomplish this we utilized the math5 null (math5 −/− ) mouse, a mutant lacking retinal ganglion cells and central projections.