Differentiation of Enantiomers by Capillary Electrophoresis

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• 作者：Gerhard K. E. Scriba (12)
  
• 关键词：Capillary electrophoresis ; Chiral selector ; Electrokinetic chromatography ; Enantiodifferentiation ; Enantiomer migration order ; Micellar electrokinetic chromatography ; Microemulsion electrokinetic chromatography ; Mobility model ; Selector–selectand complex
• 刊名：Topics in Current Chemistry
• 出版年：2013
• 出版时间：2013
• 年：2013
• 卷：340
• 期：1
• 页码：277-280
• 全文大小：2473KB
• 作者单位：Gerhard K. E. Scriba (12)
  
  12. Department of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University Jena, Philosophenweg 14, 07743, Jena, Germany
  
• ISSN：1436-5049

文摘

Capillary electrophoresis (CE) has matured to one of the major liquid phase enantiodifferentiation techniques since the first report in 1985. This can be primarily attributed to the flexibility as well as the various modes available including electrokinetic chromatography (EKC), micellar electrokinetic chromatography (MEKC), and microemulsion electrokinetic chromatography (MEEKC). In contrast to chromatographic techniques, the chiral selector is mobile in the background electrolyte. Furthermore, a large variety of chiral selectors are available that can be easily combined in the same separation system. In addition, the migration order of the enantiomers can be adjusted by a number of approaches. In CE enantiodifferentiations the separation principle is comparable to chromatography while the principle of the movement of the analytes in the capillary is based on electrophoretic phenomena. The present chapter will focus on mechanistic aspects of CE enantioseparations including enantiomer migration order and the current understanding of selector–selectand structures. Selected examples of the basic enantioseparation modes EKC, MEKC, and MEEKC will be discussed.