HPLC Separation of Enantiomers of Some Flavanone Derivatives Using Polysaccharide-Based Chiral Selectors Covalently Immobilized on Silica

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• 作者：Chiara Fanali ; Salvatore Fanali ; Bezhan Chankvetadze
• 关键词：High ; performance liquid chromatography ; Enantiomer separation ; Covalently immobilized polysaccharide ; based chiral stationary phases ; Flavanone derivatives
• 刊名：Chromatographia
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：79
• 期：3-4
• 页码：119-124
• 全文大小：1,044 KB
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• 作者单位：Chiara Fanali (1)
  Salvatore Fanali (2)
  Bezhan Chankvetadze (3)
  
  1. Centro Integrato di Ricerca, Campus Bio-Medico University, Via Alvaro del Portillo 21, 00128, Rome, Italy
  2. Institute of Chemical Methodologies, Consiglio Nazionale delle Ricerche, Area della Ricerca di Roma I, Via Salaria Km 29,300, 00015, Monterotondo, Rome, Italy
  3. Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Chavchavadze Ave 3, 0179, Tbilisi, Georgia
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Organic Chemistry
  Pharmacy
  Biochemistry
  Plant Sciences
  Measurement Science and Instrumentation
  
• 出版者：Vieweg Verlag
• ISSN：1612-1112

文摘

The separation of enantiomers of flavanone and 5 chiral flavanone derivatives was studied on two experimental polysaccharide-based chiral columns by high-performance liquid chromatography with methanol, ethanol, acetonitrile, n-hexane/ethanol and n-hexane/2-propanol as mobile phases with emphasis on the effect of analyte and chiral selector structure on separation parameters. Since chiral selectors were covalently immobilized onto the surface of silica, it was possible to use a wider variety of mobile phases in order to optimize enantioseparations. Together with the backbone of the polysaccharide, the significant role of substituents in the phenyl moiety of chiral selectors, as well as the structure of the analyte was observed on retention and enantioselectivity. Keywords High-performance liquid chromatography Enantiomer separation Covalently immobilized polysaccharide-based chiral stationary phases Flavanone derivatives