Correlation between γ-globulins and Encephalitozoon cuniculi immunoglobulins in suspected infected rabbits

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• 作者：Marco Di Giuseppe ; Paolo Romano ; Donatella Gelli…
• 关键词：Encephalitozoon cuniculi ; Rabbits ; Serum proteins ; γ ; globulins
• 刊名：Comparative Clinical Pathology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：25
• 期：6
• 页码：1237-1239
• 全文大小：266 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X
• 卷排序：25

文摘

Encephalitozoon cuniculi is a parasite that can infect a variety of animals, including immune-compromised humans. Rabbits are prone to encephalitozoonosis but the subclinical course and high serum prevalence make it difficult to diagnose with certainty in live animals. Different approaches have been used to support the presence of an active infection in symptomatic rabbits: antibodies titers, IgM and IgG serum evaluation, electrophoresis, PCR in urine, and cerebrospinal fluid analysis. In this study, 76 symptomatic rabbits were divided in three groups based on their Ig results: IgM+ IgG+, IgM-IgG+ and IgM-IgG-. By statistical analysis total serum protein was proved not to be effective in predicting an antibody response, in contrast the γ-globulin ranges from serum electrophoresis can predict whether the patient is positive for IgM and/or IgG. In fact, a significant quantitative correlation between percentage of γ-globulins and positive IgM and IgG serum for E. cuniculi was established in symptomatic rabbit. These values can be useful to perform a screening both for symptomatic and asymptomatic rabbits.