Two Case-Reports of the Limb Salvage Treatment of Osteosarcoma Consolidated with Obvious Pathological Fractures

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• 作者：Q. Cui (1)
  D. F. Li (1)
  C. Liu (1)
  J. Guo (1)
  S. B. Liu (1)
  Y. S. Liu (1)
  J. M. Zhai (2)
  Yanjun Zeng (2)
  
• 关键词：Osteosarcoma ; Pathological fracture ; Limb salvage treatment ; Chemotherapy
• 刊名：Pathology & Oncology Research
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：17
• 期：4
• 页码：973-979
• 全文大小：467KB
• 参考文献：1. McKenna RJ, Schwinn CP, Soong KY et al (1966) Sarcomata of osteogenic series: an analysis of 553 cases. J Bone Joint Surg Am 48:1-6
  2. Krugluger J, Gisinger B, Windhager R, Salzer-Kuntschik M,Kotz R (1993) Fracture in osteosarcoma. J Bone Joint Surg [Br] 75:210
  3. Kim MS, Lee SY, Lee TR et al (2009) Prognostic nomogram for predicting the 5?year probability of developing metastasis after neo-adjuvant chemotherapy and definitive surgery for AJCC stage II extremity osteosarcoma. Ann Oncol 20:955-60 CrossRef
  4. Bramer JA, van Linge JH, Grimer RJ, Scholten RJ (2009) Prognostic factors in localized extremity osteosarcoma: A systematic review. Eur J Surg Oncol 35(10):1030-036 CrossRef
  5. Scully SP, Ghert MA, Zurakowski D, Thompson RC, Gebhardt MC.Pathologic fracture in osteosarcoma : prognostic importance and treatment implications. J Bone Joint Surg Am. 2002;84-A:49-57.
  6. Shin KH, Rougraff BT, Simon MA (1994) Oncologic outcome of primary bone sarcoma of the pelvis. Clin Orthop 304:207-17
  7. Jaffe N, Spears R, Eftekhari F et al (1987) Impact of chemotherapy on primary tumor and survival. Cancer 59(4):701-09 CrossRef
  8. Adubu A, Sferopoulos NK, Tillman RM et al (1996) The surgical treatment and outcome of pathological fractures in localised osteosarcoma. J Bone Joint Surg Br 78(5):694-
  9. Zeifang F, Sabo D, Ewerbeck V (2000) Pathological fracture in primary malignant bone tumors. Chirurg 71(9):1121-125 CrossRef
  10. Mayil V, Natarajan RH, Govardhan S et al (2000) Limb salvage sugery for for pathological fractures in osteosarcoma. Int Orthop 24:170-72 CrossRef
  11. Bacci G, Ferrari S, Longhi A (2003) Nonmetastatic osteosarcoma of the extremity with pathologic fracture at presentation:local and systemic control by amputation or limb salvage after preoperative chemotherapy. Acta Orthop Scand 74(4):449-4 CrossRef
  12. Ebeid W, Amin S, Abdelmegid A (2005) Limb Salvage Management of Pathologic Fractures of Primary Malignant Bone Tumors. Cancer Control 12(1):57-1
  13. Rongli Y, Yi G, Wanpeng X et al (2004) Surgical Treatment of Pathological Fracture Caused by Bone Tumor. Chin J Clin Oncol 31(11):620-23
  14. Huai J, Jian-jun L, Wei X et al (2008) Neoadjuvant chemotherapy combined with limb salvage surgery for treatment of extremity osteosarcoma with pathological fracture. Journal of Clinical Orthopaedics 11(3):236-39
  15. Yibo W, Li DF (2002) Experimental and clinical of the caffeine as a cancer enhancer. Chin J Clin Oncol 29(6):450-53
  16. Eilber FC, Rosen G, Eckardt J et al (2001) Treatment-induced pathologic necrosis:a predictor of local recurrence and survival in patients receiving neoadjuvant therapy for high-grade extremity soft tissue sarcomas. J Clin Oncol 19(13):3203-209
  
• 作者单位：Q. Cui (1)
  D. F. Li (1)
  C. Liu (1)
  J. Guo (1)
  S. B. Liu (1)
  Y. S. Liu (1)
  J. M. Zhai (2)
  Yanjun Zeng (2)
  
  1. Department of Bone Tumor, Academy of Military Medical Sciences, No.8 of East Avenue, Fengtai District, Beijing, 100071, China
  2. Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing, 100022, China
  
• ISSN：1532-2807

文摘

Objective The effect of the limb salvage of the treatment of Osteosarcoma Consolidated with Obvious Pathological Fractures is not very well, the purpose of this paper is to track the efficacy of limb salvage treatment when the patients accepted the artery intervention chemotherapy and enclosed 2 clinical case-reports. Methods From January 2003 to September 2005, 2 clinical cases which one is a male, 29?years old, was confirmed osteosarcoma on the left distal femur, and the other is a female, 15?years old and has osteosarcoma on the right arm with obvious pathological fracture. After receiving arterial chemotherapy pump embedded, then started chemotherapy after the tumor biopsy, and the next process prosthesis replacement in limb salvage surgery after 5 times chemotherapy, follow on the next 5 times chemotherapy after the surgery. Results With an average follow-up 70?months, there are no postoperative infection and prosthesis loosening found, also didn’t detected tumor recurrence and metastasis, and the limb function recovered well. Conclusions With the effective, neoadjuvant chemotherapy and comprehensive treatment, salvage treatment is not the contraindication of the patients with pathological fractures of combined primary osteosarcoma, and the treatment with long-term follow-up effectively.