Molecular scissors and their application in genetically modified farm animals
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- 作者：Bjoern Petersen ; Heiner Niemann
- 关键词：Zinc ; finger nucleases ; Transcription ; activator like endonucleases ; Meganucleases ; CRISPR/Cas9 ; Molecular scissors ; Transgenic animals ; Gene targeting ; Genome editing
- 刊名：Transgenic Research
- 出版年：2015
- 出版时间：June 2015
- 年：2015
- 卷：24
- 期：3
- 页码：381-396
- 全文大小：773 KB
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Heiner Niemann (1) (2)
1. Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Hoeltystrasse 10, 31535, Neustadt, Mariensee, Germany
2. Rebirth, Cluster of Excellence, Hannover Medical School, Hannover, Germany - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Molecular Medicine
Plant Genetics and Genomics
Animal Genetics and Genomics
Plant Sciences
Human Genetics - 出版者：Springer Netherlands
- ISSN：1573-9368
文摘
Molecular scissors (MS), incl. Zinc Finger Nucleases (ZFN), Transcription-activator like endoncleases (TALENS) and meganucleases possess long recognition sites and are thus capable of cutting DNA in a very specific manner. These molecular scissors mediate targeted genetic alterations by enhancing the DNA mutation rate via induction of double-strand breaks at a predetermined genomic site. Compared to conventional homologous recombination based gene targeting, MS can increase the targeting rate 10,000-fold, and gene disruption via mutagenic DNA repair is stimulated at a similar frequency. The successful application of different MS has been shown in different organisms, including insects, amphibians, plants, nematodes, and mammals, including humans. Recently, another novel class of molecular scissors was described that uses RNAs to target a specific genomic site. The CRISPR/Cas9 system is capable of targeting even multiple genomic sites in one shot and thus could be superior to ZFNs or TALEN, especially by its easy design. MS can be successfully employed for improving the understanding of complex physiological systems, producing transgenic animals, incl. creating large animal models for human diseases, creating specific cell lines, and plants, and even for treating human genetic diseases. This review provides an update on molecular scissors, their underlying mechanism and focuses on new opportunities for generating genetically modified farm animals.