Structural insight into CIDE domains: the Janus face of CIDEs

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• 作者：Hyun Ho Park
• 关键词：Apoptosis ; DNA fragmentation ; CIDE domain ; Molecular structure
• 刊名：Apoptosis
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：20
• 期：2
• 页码：240-249
• 全文大小：5,387 KB
• 参考文献：1. Batistatou A, Greene LA (1993) Internucleosomal DNA cleavage and neuronal cell survival/death. J Cell Biol 122:523-32 CrossRef
  2. Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P et al (1999) Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Cell 99:747-55 CrossRef
  3. Zhou P, Lugovskoy AA, McCarty JS, Li P, Wagner G (2001) Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. Proc Natl Acad Sci USA 98:6051-055 CrossRef
  4. Liu X, Zou H, Slaughter C, Wang X (1997) DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89:175-84 CrossRef
  5. Sakahira H, Enari M, Nagata S (1999) Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S. J Biol Chem 274:15740-5744 CrossRef
  6. Sabol SL, Li R, Lee TY, Abdul-Khalek R (1998) Inhibition of apoptosis-associated DNA fragmentation activity in nonapoptotic cells: the role of DNA fragmentation factor-45 (DFF45/ICAD). Biochem Biophys Res Commun 253:151-58 CrossRef
  7. Gu J, Dong RP, Zhang C, McLaughlin DF, Wu MX et al (1999) Functional interaction of DFF35 and DFF45 with caspase-activated DNA fragmentation nuclease DFF40. J Biol Chem 274:20759-0762 CrossRef
  8. Inohara N, Koseki T, Chen S, Wu X, Nunez G (1998) CIDE, a novel family of cell death activators with homology to the 45?kDa subunit of the DNA fragmentation factor. EMBO J 17:2526-533 CrossRef
  9. Chen Z, Guo K, Toh SY, Zhou Z, Li P (2000) Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis. J Biol Chem 275:22619-2622 CrossRef
  10. Liang L, Zhao M, Xu Z, Yokoyama KK, Li T (2003) Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family. Biochem J 370:195-03 CrossRef
  11. Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T et al (2008) FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 118:2808-821
  12. Lin SC, Li P (2004) CIDE-A, a novel link between brown adipose tissue and obesity. Trends Mol Med 10:434-39 CrossRef
  13. Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP et al (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet 35:49-6 CrossRef
  14. Li JZ, Ye J, Xue B, Qi J, Zhang J et al (2007) Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation. Diabetes 56:2523-532 CrossRef
  15. Park OK, Park HH (2012) Dual apoptotic DNA fragmentation system in the fly: Drep2 is a novel nuclease of which activity is inhibited by Drep3. FEBS Lett 586:3085-089 CrossRef
  16. Lee SM, Park HH (2014) In vitro analysis of the complete CIDE domain interactions of the Drep system in fly. Apoptosis 19:428-35 CrossRef
  17. Cotter TG (2009) Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer 9:501-07
• 作者单位：Hyun Ho Park (1) (2)
  
  1. School of Biotechnology and Graduate School of Biochemistry, Yeungnam University, Gyeongsan, South Korea
  2. Department of Biotechnology, Yeungnam University, Gyeongsan, South Korea
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  Cell Biology
  Biochemistry
  Virology
  
• 出版者：Springer Netherlands
• ISSN：1573-675X

文摘

Cell-death inducing DFF45-like effect domain (CIDE domain) is a protein interaction module that was initially found in DNA fragmentation factor (DFF) proteins DFF40 and DFF45. Several other CIDE-containing proteins, CIDE-A, CIDE-B, and CIDE-3, have since been identified in humans. Although the main function of these proteins is associated with apoptosis, recent studies have identified roles of CIDE-containing proteins in energy metabolism, especially involvement in control of the size of lipid droplets. Because CIDE-containing proteins perform critical tasks in apoptosis and energy metabolism and have been linked to many human diseases including cancer and obesity, studies of CIDE domains and CIDE-containing proteins are of great biological importance. This review summarizes the structural insight into CIDE and the CIDE–CIDE complex and speculates on a generalized strategy for the CIDE–CIDE interaction based on the available CIDE structures and molecular modelling.