Novel double-walled microspheres based on chitosan, sodium cellulose sulfate and sodium tripolyphosphate: Preparation, characterization and in vitro release study

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• 作者：Li-Ying Zhu (1) (2)
  Xiao-Qin Yan (1)
  Hong-Man Zhang (1)
  Shan-Jing Yao (2)
  Ling Jiang (3)
  
  1. College of Sciences ; Nanjing University of Technology ; Nanjing ; 211816 ; P. R. China
  2. Department of Chemical and Biological Engineering ; Zhejiang University ; Hangzhou ; 310027 ; P. R. China
  3. College of Food Science and Light Industry ; Nanjing University of Technology ; Nanjing ; 211816 ; P. R. China
  
• 关键词：Chitosan ; Sodium Cellulose Sulfate ; Sodium Tripolyphosphate ; Double ; walled Microshperes ; In Vitro Drug Release
• 刊名：Korean Journal of Chemical Engineering
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：32
• 期：3
• 页码：369-372
• 全文大小：597 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Industrial Chemistry and Chemical Engineering
  Catalysis
  Materials Science
  Biotechnology
  
• 出版者：Springer New York
• ISSN：1975-7220

文摘

A novel double-walled microsphere composed of chitosan, sodium cellulose sulfate (NaCS) and sodium tripolyphosphate (TPP) was prepared. TPP was used as ionic crosslinker. The morphology of the microspheres was observed by microscope and SEM, and the results showed that the double-walled microsphere was smooth outside, with rough interior surface. FTIR spectra analysis was performed to investigate the PEC formation among chitosan, NaCS, and TPP. In vitro release studies of BSA showed that the double-walled microspheres had regular and sustainable release profiles in simulated colonic fluid (SCF). Our results indicated that the double-walled microspheres prepared could be used as a candidate protein drug carrier for the colon.