Whole genome sequencing in cats, identifies new models for blindness in AIPL1 and somite segmentation in HES7
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- 作者：Leslie A. Lyons ; Erica K. Creighton ; Hasan Alhaddad ; Holly C. Beale…
- 关键词：Aryl ; hydrocarbon ; interacting receptor protein ; like 1 ; Domestic cat ; Felis silvestris catus ; Hairy and Enhancer of Split 7 ; LCA4 ; Progressive retinal atrophy
- 刊名：BMC Genomics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：766 KB
- 刊物主题：Life Sciences, general; Microarrays; Proteomics; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics;
- 出版者：BioMed Central
- ISSN：1471-2164
文摘
Background The reduced cost and improved efficiency of whole genome sequencing (WGS) is drastically improving the development of cats as biomedical models. Persian cats are models for Leber’s congenital amaurosis (LCA), the most severe and earliest onset form of visual impairment in humans. Cats with innocuous breed-defining traits, such as a bobbed tail, can also be models for somite segmentation and vertebral column development.