Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling
详细信息 查看全文
- 作者：Cuicui Zhu ; Yi Yu ; Jean-Pierre Montani ; Xiu-Fen Ming ; Zhihong Yang
- 关键词：Arginase ; I ; Endothelial cell ; eNOS ; uncoupling ; Inflammation ; Senescence
- 刊名：BMC Research Notes
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：1322KB
- 刊物主题：Biomedicine, general; Medicine/Public Health, general; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1756-0500
- 卷排序：10
文摘
BackgroundAugmented arginase-II (Arg-II) is implicated in endothelial senescence and inflammation through a mutual positive regulatory circuit with S6K1. This study was conducted to investigate whether Arg-I, another isoform of arginase that has been also reported to play a role in vascular endothelial dysfunction, promotes endothelial senescence through similar mechanisms.