A simple and inexpensive enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine

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• 作者：Darren S. Miller ; Anne Michelle Parsons…
• 关键词：Breath testing ; Pig ; Endoscopic capsule ; Gastric emptying ; Biomarker delivery ; Gastrointestinal tract ; ; /li> /li> /li> R965
• 刊名：Journal of Zhejiang University SCIENCE B
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：16
• 期：7
• 页码：586-592
• 全文大小：868 KB
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  Symonds
• 作者单位：Darren S. Miller (1)
  Anne Michelle Parsons (1) (2)
  John Bresland (2)
  Paul Herde (3)
  Duc Minh Pham (1)
  Angel Tan (4)
  Hung-yao Hsu (1)
  Clive A. Prestidge (4)
  Tim Kuchel (3)
  Rezaul Begg (5)
  Syed Mahfuzul Aziz (1)
  Ross N. Butler (2)
  
  1. Division of Information Technology, Engineering and the Environment, School of Engineering, University of South Australia, Mawson Lakes, SA, 5095, Australia
  2. Division of Health Sciences, School of Pharmacy and Medical Science, University of South Australia, Adelaide, SA, 5000, Australia
  3. Large Animal Research and Imaging Facility, South Australian Health & Medical Research Institute (SAHMRI), Gilles Plains, SA, 5086, Australia
  4. Ian Wark Research Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia
  5. Gait and Balance Research Group, Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, VIC, 3032, Australia
  
• 刊物主题：Biomedicine general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1862-1783

文摘

Understanding the ecology of the gastrointestinal tract and the impact of the contents on the host mucosa is emerging as an important area for defining both wellness and susceptibility to disease. Targeted delivery of drugs to treat specific small intestinal disorders such as small bowel bacterial overgrowth and targeting molecules to interrogate or to deliver vaccines to the remote regions of the small intestine has proven difficult. There is an unmet need for methodologies to release probes/drugs to remote regions of the gastrointestinal tract in furthering our understanding of gut health and pathogenesis. In order to address this concern, we need to know how the regional delivery of a surrogate labeled test compound is handled and in turn, if delivered locally as a liquid or powder, the dynamics of its subsequent handling and metabolism. In the studies we report on in this paper, we chose 13C sodium acetate (13C-acetate), which is a stable isotope probe that once absorbed in the small intestine can be readily measured non-invasively by collection and analysis of 13CO2 in the breath. This would provide information of gastric emptying rates and an indication of the site of release and absorptive capacity. In a series of in vitro and in vivo pig experiments, we assessed the enteric-protective properties of a commercially available polymer EUDRAGIT L100-55 on gelatin capsules and also on DRcaps. Test results demonstrated that DRcaps coated with EUDRAGIT L100-55 possessed enhanced enteric-protective properties, particularly in vivo. These studies add to the body of knowledge regarding gastric emptying in pigs and also begin the process of gathering specifications for the design of a simple and cost-effective enteric-coated capsule for delivery of acid-labile macromolecules to the small intestine.