Kafirin polymer film for enteric coating on HPMC and Gelatin capsules

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• 作者：Sumit S. Lal ; Pooja Tanna ; Sandeep Kale ; Shashank T. Mhaske
• 刊名：Journal of Materials Science
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：52
• 期：7
• 页码：3806-3820
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Materials Science, general; Characterization and Evaluation of Materials; Polymer Sciences; Continuum Mechanics and Mechanics of Materials; Crystallography and Scattering Methods; Classical Mechanics;
• 出版者：Springer US
• ISSN：1573-4803
• 卷排序：52

文摘

Protein-based materials have attracted a tremendous attention to the growth of polymer films and protein-based coating. Efficiency of Kafirin film and effect of Kafirin film as an enteric coating for drug release was studied. The cast films with varying plasticizer concentrations (polyethylene glycol-300) were tested for mechanical tests (Tensile, Young’s, Elongation) and further analyzed with DSC and TGA analysis. Swelling behavior and FTIR were performed to ensure medium uptake and inter- and intra-molecule structural changes. All together for enteric coating, capsules filled with Paracetamol were dip coated in Kafirin solution with 20, 30, and 40% of PEG plasticizer of drug release study. Dissolution studies demonstrated zero release upon exposure to 0.1 N HCl of pH 1.2 for initial 2 h, and gradual release was observed upon exposure to phosphate buffer of pH 6.8. The effect of plasticizer concentration was noticeable in the case of HPMC capsules, and drug release declined with the increasing plasticizer content. Whereas, in case of Gelatin opposite results were obtained. This work has shown that Kafirin protein has a potential for use as an enteric coating for drug delivery application.