Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis

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• 作者：Callinice D. Capo-chichi ; Toni M. Yeasky ; Elizabeth R. Smith…
• 关键词：Nuclear envelope ; Lamin A/C ; Aneuploidy ; Polyploidy ; Ovarian cancer ; Carcinomas
• 刊名：BMC Cell Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：2428KB
• 刊物主题：Cell Biology; Biological Microscopy; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1471-2121
• 卷排序：17

文摘

BackgroundThe Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is extensive aneuploidy caused by chromosomal numerical instability, which is thought to promote malignant transformation. Conventionally, aneuploidy is thought to be the result of mitotic errors and chromosomal nondisjunction during mitosis. Previously, we found that ovarian cancer cells often lost or reduced nuclear lamina proteins lamin A/C, and suppression of lamin A/C in cultured ovarian epithelial cells leads to aneuploidy. Following up, we investigated the mechanisms of lamin A/C-suppression in promoting aneuploidy and synergy with p53 inactivation.