Nuclear envelope structural proteins facilitate nuclear shape changes accompanying embryonic differentiation and fidelity of gene expression
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- 作者：Elizabeth R. Smith ; Yue Meng ; Robert Moore ; Jeffrey D. Tse ; Arn G. Xu…
- 关键词：Mouse ES cells ; Retinoic acid ; Lamin A/C ; Emerin ; Nuclear envelope ; Endoderm
- 刊名：BMC Cell Biology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：5790KB
- 刊物主题：Cell Biology; Biological Microscopy; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1471-2121
- 卷排序：18
文摘
BackgroundNuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural proteins were upregulated when murine embryonic stem (ES) cells differentiated to primitive endoderm cells. Here we further investigated the morphological changes of nuclei that accompany this differentiation.