Polycyclic aromatic hydrocarbons and childhood asthma

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• 作者：Parisa Karimi (1) (3)
  Kamau O. Peters (1)
  Katayoon Bidad (2)
  Paul T. Strickland (1)
  
  1. Program in Occupational and Environmental Health ; Department of Environmental Health Sciences ; Johns Hopkins Bloomberg School of Public Health ; 615 North Wolfe Street ; Room E7535 ; Baltimore ; MD ; USA
  3. Department of Environmental and Occupational Health ; Milken Institute School of Public Health ; George Washington University ; Washington ; DC ; USA
  2. Immunology ; Asthma and Allergy Research Institute ; Tehran University of Medical Sciences ; Tehran ; Iran
  
• 关键词：Polycyclic aromatic hydrocarbons ; Childhood asthma ; Incidence ; Prevalence ; Mortality ; Morbidity
• 刊名：European Journal of Epidemiology
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：30
• 期：2
• 页码：91-101
• 全文大小：647 KB
• 参考文献：1. Bousquet, J, Jeffery, PK, Busse, WW, Johnson, M, Vignola, AM (2000) Asthma from bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 161: pp. 1720-1745
  2. Lai, C, Beasley, R, Crane, J, Foliaki, S, Shah, J, Weiland, S (2009) Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 64: pp. 476-483
  3. Akinbami LJ. The Stat of childhood asthma, United States, 1980鈥?005. Advance data from vita and health statistics; no 381. Hyattsville, MD: National Center for Health Statistics; 2006.
  4. Moorman JE, Rudd RA, Johnson CA, King M, Minor P, Bailey C, Scalia MS, Akinbami LJ. National surveillance for asthma鈥擴nited States, 1980鈥?004. Department of Health and Human Services, Centers for Disease Control and Prevention; 2007.
  5. National Heart, Lung, and Blood Institute. Morbidity and mortality: chart book on cardiovascular, lung, and blood diseases. Bethesda, Md: National Institutes of Health; 2009.
  6. Braman, SS (2006) The global burden of asthma. Chest 130: pp. 4S-12S
  7. Almqvist, C, Worm, M, Leynaert, B (2008) Impact of gender on asthma in childhood and adolescence: a GA2LEN review. Allergy 63: pp. 47-57
  8. Rabe KF, Adachi M, Lai CK, Soriano JB, Vermeire PA, Weiss KB, Weiss ST. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol. 2004;114:40鈥?0.
  9. Smyth, RL (2002) Asthma: a major pediatric health issue. Respir Res 3: pp. S3-S7
  10. Measuring childhood asthma prevalence before and after the 1997 redesign of the National Health Interview Survey鈥擴nited States. MMWR Morb Mortal Wkly Rep. 2000;49:908鈥?1.
  11. Bryant-Stephens, T (2009) Asthma disparities in urban environments. J Allergy Clin Immunol 123: pp. 1199-1206
  12. Akinbami, LJ, Schoendorf, KC (2002) Trends in childhood asthma: prevalence, health care utilization, and mortality. Pediatrics 110: pp. 315-322
  13. Britton, J (1992) Asthma鈥檚 changing prevalence. BMJ 304: pp. 857-858
  14. Woolcock, AJ (1996) Asthma-disease of a modern lifestyle. Med J Aust 165: pp. 358-359
  15. Cookson, J (1987) Prevalence rates of asthma in developing countries and their comparison with those in Europe and North America. Chest 91: pp. 97S-103S
  16. Gupta, RS, Carri贸n-Carire, V, Weiss, KB (2006) The widening black/white gap in asthma hospitalizations and mortality. J Allergy Clin Immunol 117: pp. 351-358
  17. Akinbami, LJ, Moorman, JE, Garbe, PL, Sondik, EJ (2009) Status of childhood asthma in the United States, 1980鈥?007. Pediatrics 123: pp. S131-S145
  18. Cairns, CB (2006) Acute asthma exacerbations: phenotypes and management. Clin Chest Med 27: pp. 99-108
  19. Calamelli, E, Ricci, G, Pession, A (2012) Recent advances in diagnosis and therapy of allergic rhinitis and asthma in childhood. Eur Ann Allergy Clin Immunol 44: pp. 215-224
  20. Nishimuta, T, Kondo, N, Hamasaki, Y, Morikawa, A, Nishima, S (2011) Childhood asthma. Allergol Int 60: pp. 147-169
  21. McFadden, E, Warren, EL (1997) Observations on asthma mortality. Ann Intern Med 127: pp. 142-147
  22. Anderson, HR, Gupta, R, Kapetanakis, V, Asher, MI, Clayton, T, Robertson, CF, Strachan, DP (2008) ISAAC streeting committee. International correlations between indicators of prevalence, hospital admissions and mortality for asthma in children. Int J Epidemiol 37: pp. 573-582
  23. Herzog, R, Cunningham-Rundles, S (2011) Pediatric asthma: natural history, assessment, and treatment. Mt Sinai J Med 78: pp. 645-660
  24. Miller, JE (2000) The effects of race/ethnicity and income on early childhood asthma prevalence and health care use. Am J Public Health 90: pp. 428-430
  25. Salam, MT, Li, YF, Langholz, B, Gilliland, FD (2004) Early-life environmental risk factors for asthma: findings from the Children鈥檚 Health Study. Environ Health Perspect 112: pp. 760-765
  26. Sears, MR, Holdaway, MD, Flannery, EM, Herbison, GP, Silva, PA (1996) Parental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma. Arch Dis Child 75: pp. 392-398
  27. Aligne, CA, Auinger, P, Byrd, RS, Weitzman, M (2000) Risk factors for pediatric asthma. Contributions of poverty, race, and urban residence. Am J Respir Crit Care Med 162: pp. 873-877
  28. MacDowell, AL, Bacharier, LB (2005) Infectious triggers of asthma. Immunol Allergy Clin North Am 25: pp. 45-66
  29. Shaheen, SO (1999) Obesity and asthma: cause for concern?. Clin Exp Allergy 29: pp. 291-293
  30. Infante-Rivard, C, Amre, D, Gautrin, D, Malo, JL (2001) Family size, day-care attendance, and breastfeeding in relation to the incidence of childhood asthma. Am J Epidemiol 153: pp. 653-658
  31. Devereux, G, Seaton, A (2005) Diet as a risk factor for atopy and asthma. J Allergy Clin Immunol 115: pp. 1109-1117
  32. Guilbert TW, Morgan WJ, Zeiger RS, Bacharier LB, Boehmer SJ, Krawiec M, Larsen G, Lemanske RF, Liu A, Mauger DT, Sorkness C, Szefler SJ, Strunk RC, Taussig LM, Martinez FD. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol. 2004;114:1282鈥?.
  33. Bacharier, LB, Guilbert, TW (2012) Diagnosis and management of early asthma in preschool-aged children. J Allergy Clin Immunol 130: pp. 287-296
  34. Oddy, WH, Holt, PG, Sly, PD, Read, AW, Landau, LI, Stanley, FJ, Kendall, GE, Burton, PR (1999) Association between breast feeding and asthma in 6聽year old children: findings of a prospective birth cohort study. BMJ 319: pp. 815-819
  35. Peat, JK, Allen, J, Oddy, W, Webb, K (2003) Breastfeeding and asthma: appraising the controversy. Pediatr Pulmonol 35: pp. 331-334
  36. Karimi, P, Shahrokni, A, Moradi, S (2013) Evidence for US Preventive Services Task Force (USPSTF) Recommendations against routine mammography for females between 40鈥?9 years of age. Asian Pac J Cancer Prev 14: pp. 2137-2139
  37. Green, RM, Custovic, A, Sanderson, G, Hunter, J, Johnston, SL, Woodcock, A (2002) Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ 324: pp. 763
  38. Gern, JE (2000) Viral and bacterial infections in the development and progression of asthma. J Allergy Clin Immunol 105: pp. S497-S502
  39. Massie, J (2002) Exercise-induced asthma in children. Pediatric Drugs 4: pp. 267-278
  40. Mireku, N, Wang, Y, Ager, J, Reddy, RC, Baptist, AP (2009) Changes in weather and the effects on pediatric asthma exacerbations. Ann Allergy Asthma Immunol 103: pp. 220-224
  41. Wu, F, Takaro, TK (2007) Childhood asthma and environmental interventions. Environ Health Perspect 115: pp. 971-975
  42. Rumchev, K, Spickett, J, Bulsara, M, Phillips, M, Stick, S (2004) Association of domestic exposure to volatile organic compounds with asthma in young children. Thorax 59: pp. 746-751
  43. Burton, A (2009) Children鈥檚 health: methylation links prenatal PAH exposure to asthma. Environ Health Perspect 117: pp. A195
  44. Delfino, RJ (2002) Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. Environ Health Perspect 110: pp. 573
  45. Cerniglia, CE (1993) Biodegradation of polycyclic aromatic hydrocarbons. Curr Opin Biotechnol 4: pp. 331-338
  46. Connell DW, Hawker DW, Warne MJ, Vowles PP. Polycyclic aromatic hydrocarbons (PAHs). In: Connell DW, editor. Basic concepts of environmental chemistry. Boca Raton, FL: CRC Press; 1997. p. 205鈥?7.
  47. Srogi, K (2007) Monitoring of environmental exposure to polycyclic aromatic hydrocarbons: a review. Environ Chem Lett 5: pp. 169-195
  48. Franco, SS, Nardocci, AC, G眉nther, WMR (2008) PAH biomarkers for human health risk assessment: a review of the state-of-the-art. Cad Saude Publica 24: pp. S569-S580
  49. Shimada, T (2006) Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. Drug Metab Pharmacokinet 21: pp. 257-276
  50. Baird, WM, Hooven, LA, Mahadevan, B (2005) Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen 45: pp. 106-114
  51. Jongeneelen, FJ (2001) Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons. Ann Occup Hyg 45: pp. 3-13
  52. Chuang, JC, Callahan, PJ, Lyu, CW, Wilson, NK (1999) Polycyclic aromatic hydrocarbon exposures of children in low-income families. J Expo Anal Environ Epidemiol 9: pp. 85-98
  53. Strickland, P, Kang, D (1999) Urinary 1-hydroxypyrene and other PAH metabolites as biomarkers of exposure to environmental PAH in air particulate matter. Toxicol Lett 108: pp. 191-199
  54. Rappaport, SM, Waidyanatha, S, Serdar, B (2004) Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons. J Environ Monit 6: pp. 413-416
  55. Ramesh, A, Walker, SA, Hood, DB, Guill茅n, MD, Schneider, K, Weyand, EH (2004) Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons. Int J Toxicol 23: pp. 301-333
  56. Kamangar, F, Karimi, P (2013) The state of nutritional epidemiology: why we are still unsure of what we should eat?. Arch Iran Med 16: pp. 483-486
  57. Lioy, PL, Waldman, JM, Greenberg, A, Harkov, R, Pietarinen, C (1998) The Total Human Environmental Exposure Study (THEES) to benzo (a) pyrene: comparison of the inhalation and food pathways. Arch Environ Health 43: pp. 304-312
  58. Falco, G, Domingo, JL, Llobet, JM, Teixido, A, Casas, C, Muller, L (2003) Polycyclic aromatic hydrocarbons in foods: human exposure through the diet in Catalonia, Spain. J Food Prot 66: pp. 2325-2331
  59. Wenzl, T, Simon, R, Anklam, E, Kleiner, J (2006) Analytical methods for polycyclic aromatic hydrocarbons (PAHs) in food and the environment needed for new food legislation in the European Union. Trends Analyt Chem 25: pp. 716-725
  60. Kobayashi, R, Okamoto, RA, Maddalena, RL, Kado, NY (2008) Polycyclic aromatic hydrocarbons in edible grain: a pilot study of agricultural crops as a human exposure pathway for environmental contaminants using wheat as a model crop. Environ Res 107: pp. 145-151
  61. Gadde, B, Bonnet, S, Menke, C, Garivait, S (2009) Air pollutant emissions from rice straw open field burning in India, Thailand and the Philippines. Environ Pollut 157: pp. 1554-1558
  62. Nam, JJ, Thomas, GO, Jaward, FM, Steinnes, E, Gustafsson, O, Jones, KC (2008) PAHs in background soils from Western Europe: influence of atmospheric deposition and soil organic matter. Chemosphere 70: pp. 1596-1602
  63. Pufulete, M, Battershill, J, Boobis, A, Fielder, R (2004) Approaches to carcinogenic risk assessment for polycyclic aromatic hydrocarbons: a UK perspective. Regul Toxicol Pharmacol 40: pp. 54-66
  64. Fagundes, RB, Abnet, CC, Strickland, PT, Kamangar, F, Roth, MJ, Taylor, PR, Dawsey, SM (2006) Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking mate in healthy subjects from Rio Grande do Sul, Brazil. BMC Cancer 6: pp. 139
  65. Kang, D, Rothman, N, Cho, SH, Lim, HS, Kwon, HJ, Kim, SM, Schwartz, B, Strickland, PT (1995) Association of exposure to polycyclic aromatic hydrocarbons (estimated from job category) with concentration of 1-hydroxypyrene glucuronide in urine from workers at a steel plant. Occup Environ Med 52: pp. 593-599
  66. Rooij, JG, Veeger, MM, Bodelier-Bade, MM, Scheepers, PT, Jongeneelen, FJ (1994) Smoking and dietary intake of polycyclic aromatic hydrocarbons as sources of interindividual variability in the baseline excretion of 1-hydroxypyrene in urine. Int Arch Occup Environ Health 66: pp. 55-65
  67. Lee, KH, Vermeulen, R, Lenters, V, Cho, SH, Strickland, PT, Kang, D (2009) Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children. Int Arch Occup Environ Health 82: pp. 961-968
  68. Taioli, E, Sram, RJ, Garte, S, Kalina, I, Popov, TA, Farmer, PB (2007) Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage (EXPAH project): description of the population under study. Muta Res 620: pp. 1-6
  69. Horwood, L, Fergusson, D, Shannon, F (1985) Social and familial factors in the development of early childhood asthma. Pediatrics 75: pp. 859-868
  70. Hogstedt, C, Jansson, C, Hugosson, M, Tinnerberg, H, Gustavsson, P (2013) Cancer incidence in a cohort of Swedish chimney sweeps, 1958鈥?006. Am J Public Health 103: pp. 1708-1714
  71. Liu, HH, Lin, MH, Chan, CI, Chen, HL (2010) Oxidative damage in foundry workers occupationally co-exposed to PAHs and metals. Int J Hyg Environ Health 213: pp. 93-98
  72. Campo, L, Fustinoni, S, Consonni, D, Pavanello, S, Kapka, L, Siwinska, E, Mielzynska, D, Bertazzi, P (2014) Urinary carcinogenic 4鈥? ring polycyclic aromatic hydrocarbons in coke oven workers and in subjects belonging to the general population: Role of occupational and environmental exposure. Int J Hyg Environ Health 217: pp. 231-238
  73. Kuo, CY, Chang, SH, Chien, YC, Chiang, FY, Wei, YC (2005) Exposure to carcinogenic PAHs for the vendors of broiled food. J Exp Sci Environ Epidemiol 16: pp. 410-416
  74. Oh, E, Lee, E, Im, H, Kang, HS, Jung, WW, Won, NH, Kim, EM, Sul, D (2005) Evaluation of immuno-and reproductive toxicities and association between immunotoxicological and genotoxicological parameters in waste incineration workers. Toxicoloxy 210: pp. 65-80
  75. Yang, HH, Lai, SO, Hsieh, LT, Hsueh, HJ, Chi, TW (2002) Profiles of PAH emission from steel and iron industries. Chemosphere 48: pp. 1061-1074
  76. Unwin, J, Cocker, J, Scobbie, E, Chambers, H (2006) An assessment of occupational exposure to polycyclic aromatic hydrocarbons in the UK. Ann Occup Hygiene 50: pp. 395-403
  77. Godschalk, RW, Schooten, FJ, Bartsch, H (2003) A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds. J Biochem Mol Biol 36: pp. 1-11
  78. Breysse, PN, Diette, GB, Matsui, EC, Butz, AM, Hansel, NN, McCormack, MC (2010) Indoor air pollution and asthma in children. Proc Am Thorac Soc 7: pp. 102-106
  79. Matsui, EC, Hansel, NN, McCormack, MC, Rusher, R, Breysse, PN, Diette, GB (2008) Asthma in the inner city and the indoor environment. Immunol Allergy Clin North Am 28: pp. 665-686
  80. Klepeis NE, Nelson WC, Ott WR, Robinson JP, Tsang AM, Switzer P, Behar JV, Hern SC, Engelmann WH. The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants. J Expo Anal Environ Epidemiol. 2001;11:231鈥?2.
  81. Fiala, Z, Vyskocil, A, Krajak, V, Viau, C, Ettlerova, E, Bukac, J, Fialova, D, Emminger, S (2001) Environmental exposure of small children to polycyclic aromatic hydrocarbons. Int Arch Occup Environ Health 74: pp. 411-420
  82. McCormack MC, Breysse PN, Matsui EC, Hansel NN, Williams D, Curtin-Brosnan J, Eggleston P, Dietter GB, Center for Childhood Asthma in Urban Envirnment. In-home particle concentrations and childhood asthma morbidity. Environ Health Perspect. 2009;117:294鈥?8.
  83. Diette, GB, McCormack, MC, Hansel, NN, Breysse, PN, Matsui, EC (2008) Environmental issues in managing asthma. Resp Care 53: pp. 602-617
  84. Murugesan, A, Umarani, C, Subramanian, R, Nedunchezhian, N (2009) Biodiesel as an alternative fuel for diesel engines鈥攁 review. Renew Sust Energy Rev 13: pp. 653-662
  85. Karavalakis, G, Boutsika, V, Stournas, S, Bakeas, E (2011) Biodiesel emissions profile in modern diesel vehicles. Part 2: Effect of biodiesel origin on carbonyl, PAH, nitro-PAH and oxy-PAH emissions. Sci Total Environ 409: pp. 738-747
  86. Wu, S, Tao, S, Liu, W (2006) Particle size distributions of polycyclic aromatic hydrocarbons in rural and urban atmosphere of Tianjin, China. Chemosphere 62: pp. 357-367
  Toxicological profile for polycyclic aromatic hydrocarbons. Agency for Toxic Substances and Disease Registry, Atlanta
  87. Sinha, R, Cross, A, Curtin, J, Zimmerman, T, McNutt, S, Risch, A, Holden, J (2005) Development of a food frequency questionnaire module and databases for compounds in cooked and processed meats. Mol Nutr Food Res 49: pp. 648-655
  88. Keating, GA, Bogen, KT, Chan, JM (2007) Development of a meat frequency questionnaire for use in diet and cancer studies. J Am Diet Assoc 107: pp. 1356-1362
  89. Deziel, NC, Strickland, PT, Platz, EA, Abubaker, S, Buckley, TJ (2011) Comparison of standard methods for assessing dietary intake of benzo [a] pyrene. Cancer Epidemiol Biomark Prev 20: pp. 962-970
  90. Sinha, R, Cross, AJ, Graubard, BI, Leitzmann, MF, Schatzkin, A (2009) Meat intake and mortality: a prospective study of over half a million people. Arch Intern Med 169: pp. 562-571
  91. Spiegelman, D (2010) Approaches to uncertainty in exposure assessment in environmental epidemiology. Ann Rev Public Health 31: pp. 149-163
  92. Strickland, P, Kang, D, Sithisarankul, P (1996) Polycyclic aromatic hydrocarbon metabolites in urine as biomarkers of exposure and effect. Environ Health Perspect 104: pp. 927
  93. Zhao, ZH, Quan, WY, Tian, DH (1992) Experiments on the effects of several factors on the 1-hydroxypyrene level in human urine as an indicator of exposure to polycyclic aromatic hydrocarbons. Sci Total Environ 113: pp. 197-207
  94. Kang, D, Rothman, N, Cho, SH, Lim, HS, Kwon, HJ, Kim, SM, Schwartz, B, Strickland, PT (1995) Association of exposure to polycyclic aromatic hydrocarbons (estimated from job category) with concentration of 1-hydroxypyrene glucuronide in urine from workers at a steel plant. Occup Environ Med 52: pp. 593-599
  95. Sobus, JR, Waidyanatha, S, McClean, MD, Herrick, RF, Smith, TJ, Garshick, E, Ladan, F, Hart, JE, Zheng, Y, Rappaport, SM (2009) Urinary naphthalene and phenanthrene as biomarkers of occupational exposure to polycyclic aromatic hydrocarbons. Occup Environ Med 66: pp. 99-104
  96. Krewski D, Jerrett M, Burnett RT, Ma R, Hughes E, Shi Y, Turner MC, Pope CA III, Thurston G, Calle EE, Thun MJ, Beckerman B, DeLUnca P, Finkelstein N, Ito K, Moore DK, Newbold KB, Ramsay T, Rozz Z, SHin H, Tempalski. Extended follow-up and spatial analysis of the American Cancer Society study linking particulate air pollution and mortality. Res Rep Health Eff Inst. 2009;140:5鈥?14.
  97. Garza, KM, Soto, KF, Murr, LE (2008) Cytotoxicity and reactive oxygen species generation from aggregated carbon and carbonaceous nanoparticulate materials. Int J Nanomedicine 3: pp. 83-94
  98. Perera, FP, Rauh, V, Whyatt, RM, Tsai, WY, Tang, D, Diaz, D, Hoepner, L, Barr, D, Tu, YH, Camann, D, Kinney, P (2006) Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3聽years of life among inner-city children. Environ Health Perspect 114: pp. 1287-1292
  99. Perera, FP, Li, Z, Whyatt, R, Hoepner, L, Wang, S, Camann, D, Rauh, V (2009) Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years. Pediatrics 124: pp. e195-e202
  100. Jedrychowski, W, Galas, A, Pac, A, Flak, E, Camman, D, Rauh, V, Perera, F (2005) Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life. Eur J Epidemiol 20: pp. 775-782
  101. Li, Z, Sandau, CD, Romanoff, LC, Caudill, SP, Sjodin, A, Needham, LL, Patterson, DG (2008) Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population. Environ Res 107: pp. 320-331
  102. Grainger, J, Huang, W, Patterson, DG, Turner, WE, Pirkle, J, Caudill, SP, Wang, RY, Needham, LL, Sampson, EJ (2006) Reference range levels of polycyclic aromatic hydrocarbons in the US population by measurement of urinary monohydroxy metabolites. Environ Res 100: pp. 394-423
  103. Al-Daghri NM, Alokail MS, Abd-Alrahman SH, Draz HM, Yakout SM, Clerici M. Polycyclic aromatic hydrocarbon exposure and pediatric asthma in children: a case-control study. Environ Health. 2013;12:1.
  104. Karimi, P, Islami, F, Anandasabapathy, S, Freedman, ND, Kamangar, F (2014) Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomark Prev 23: pp. 700-713
  105. Karimi, P, Shahrokni, A, Ranjbar, MR (2014) Implementation of proteomics for cancer research: past, present, and future. Asian Pac J Cancer Prev 15: pp. 2433-2438
  106. IARC. Polynuclear aromatic compounds. Part I: chemical, environmental and experimental data; 1983. Lyon: International Agency for Research on Cancer.
  107. National Toxicology Program. Public Health Service, US Department of Health and Human Services, 12th report on carcinogens. Research Triangle Park, NC; 2011. p. 353鈥?1.
  108. NTP 12th report on carcinogens. Rep Carcinog. 2011;12(499):iii-499.
  109. Jia, Y, Stone, D, Wang, W, Schrlau, J, Tao, S, Simonich, SL (2011) Estimated reduction in cancer risk due to PAH exposures if source control measures during the 2008 Beijing Olympics were sustained. Environ Health Perspect 119: pp. 815-820
  110. Brauer, M, Hoek, G, Vliet, P, Meliefste, K, Fischer, PH, Wijga, A, Koopman, LP, Gerritsen, J, Kerkhof, M, Heinrish, J, Bellander, T, Brunekreef, B (2002) Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respi Crit Care Med 166: pp. 1092-1098
  111. Vork, K, Broadwin, R, Blaisdell, R (2008) Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression. Cien Saude Colet 13: pp. 1313-1325
  112. Strachan, DP, Cook, DG (1998) Parental smoking and childhood asthma: longitudinal and case-control studies. Thorax 53: pp. 204-212
  113. Qian, Z, Zhang, J, Korn, LR, Wei, F, Chapman, RS (2004) Factor analysis of household factors: are they associated with respiratory conditions in Chinese children?. Int J Epidemiol 33: pp. 582-588
  114. Burr, M, Anderson, H, Austin, J, Harkins, L, Kaur, B, Strachan, D, Warner, JO (1999) Respiratory symptoms and home environment in children: a national survey. Thorax 54: pp. 27-32
  115. Peabody, JW, Riddell, TJ, Smith, KR, Liu, Y, Zhao, Y, Gong, J, Milet, M, Sinton, JE (2005) Indoor air pollution in rural China: cooking fuels, stoves, and health status. Arch Environ Occup Health 60: pp. 86-95
  116. Spira-Cohen, A, Chen, LC, Kendall, M, Lall, R, Thurston, GD (2011) Personal exposures to traffic-related air pollution and acute respiratory health among Bronx schoolchildren with asthma. Environ Health Perspect 119: pp. 559-565
  117. Patel, MM, Miller, RL (2009) Air pollution and childhood asthma: recent advances and future directions. Curr Opin Pediatr 21: pp. 235-242
  118. Bell, ML, Ebisu, K, Peng, RD, Dominici, F (2009) Adverse health effects of particulate air pollution: modification by air conditioning. Epidemiology 20: pp. 682-686
  119. Miller, RL, Garfinkel, R, Horton, M, Camann, D, Perera, FP, Whyatt, RM, Kinney, PL (2004) Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort. Chest 126: pp. 1071-1078
  120. Rosa, MJ, Jung, KH, Perzanowski, MS, Kelvin, EA, Darling, KW, Camann, DE, Chillrud, SN, Whyatt, RM, Kinney, PL, Perera, FP, Miller, RL (2011) Prenatal exposure to polycyclic aromatic hydrocarbons, environmental tobacco smoke and asthma. Respir Med 105: pp. 869-876
  121. Nadeau, K, McDonald-Hyman, C, Noth, EM, Pratt, B, Hammond, SK, Balmes, J, Tager, I (2010) Ambient air pollution impairs regulatory T-cell function in asthma. J. Allergy Clin Immunol 126: pp. 845-852
  122. Miller, RL, Garfinkel, R, Lendor, C, Hoepner, L, Li, Z, Romanoff, L, Sjodin, A, Needham, L, Perera, FP, Whayatt, RM (2010) Polycyclic aromatic hydrocarbon metabolite levels and pediatric allergy and asthma in an inner-city cohort. Pediatr Allergy Immunol 21: pp. 260-267
  123. Karimi, P, Modarresi, SZ, Sahraian, MA, Shoormasti, RS, Mahlooji, M, Kazemnejad, A, Pourpak, Z (2013) The relation of multiple sclerosis with allergy and atopy: a case control study. Iran J Allergy Asthma Immunol 12: pp. 182-189
  124. Perzanowski, MS, Chew, GL, Divjan, A, Jung, KH, Ridder, R, Tang, D, Diaz, D, Goldstein, IF, Kinney, PL, Rundle, AG, Camann, DE, Perera, FP, Miller, RL (2013) Early-life cockroach allergen and polycyclic aromatic hydrocarbon exposures predict cockroach sensitization among inner-city children. J Allergy Clin Immunol 131: pp. 886-893
  125. Tsien, A, Diaz-Sanchez, D, Ma, J, Saxon, A (1997) The organic component of diesel exhaust particles and phenanthrene, a major polyaromatic hydrocarbon constituent, enhances IgE production by IgE-secreting EBV-transformed human B cells in vitro. Toxicol Appl Pharmacol 142: pp. 256-263
  126. Nel, AE, Diaz-Sanchez, D, Ng, D, Hiura, T, Saxon, A (1998) Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol 102: pp. 539-554
  127. Lubitz, S, Schober, W, Pusch, G, Effner, R, Klopp, N, Behrendt, H, Buters, JT (2010) Polycyclic aromatic hydrocarbons from diesel emissions exert proallergic effects in birch pollen allergic individuals through enhanced mediator release from basophils. Environ Toxicol 25: pp. 188-197
  128. Xiao, GG, Nel, AE, Loo, JA (2005) Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles. Electrophoresis 26: pp. 280-292
  129. Kanoh, T, Suzuki, T, Ishimori, M, Ikeda, S, Ohasawa, M, Ohkuni, H, Tunetoshi, Y (1996) Adjuvant activities of pyrene, anthracene, fluoranthene and benzo(a)pyrene in production of anti-IgE antibody to Japanese cedar pollen allergen in mice. J Clin Lab Immunol 48: pp. 133-147
  130. Bommel, H, Li-Weber, M, Serfling, E, Duschl, A (2000) The environmental pollutant pyrene induces the production of IL-4. J Allergy Clin Immunol 105: pp. 796-802
  131. Cao, Y, DePinho, RA, Ernst, M, Vousden, K (2011) Cancer research: past, present and future. Nat Rev Cancer 11: pp. 749-754
  132. Diaz-Sanchez, D, Dotson, AR, Takenaka, H, Saxon, A (1994) Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J Clin Invest 94: pp. 1417-1425
  133. Riedl, MA, Nel, AE (2008) Importance of oxidative stress in the pathogenesis and treatment of asthma. Curr Opin Allergy Clin Immunol 8: pp. 49-56
  134. Voorhis, M, Knopp, S, Julliard, W, Fechner, JH, Zhang, X, Schauer, JJ, Mezrich, JD (2013) Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. PLoS ONE 8: pp. e82545
  135. Brandt, EB, Kovacic, MB, Lee, GB, Gibson, AM, Acciani, TH, Cras, TD, Ryan, PH, Budelsky, AL, Khurana Hershey, GK (2013) Diesel exhaust particle induction of IL-17A contributes to severe asthma. J Allergy Clin Immunol 132: pp. 1194-1204
  136. Li, N, Wang, M, Bramble, LA, Schmitz, DA, Schauer, JJ, Sioutas, C, Harkema, JR, Nel, AE (2009) The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential. Environ Health Perspect 117: pp. 1116-1123
  137. Mastrangelo, G, Clonfero, E, Pavanello, S, Fedeli, U, Fadda, E, Turato, A, Piccinni, S, Montagnani, R, Marcer, G (2003) Exposure to diesel exhaust enhances total IgE in non-atopic dockers. Int Arch Occup Environ Health 76: pp. 63-68
  138. Pandya, RJ, Solomon, G, Kinner, A, Balmes, JR (2002) Diesel exhaust and asthma: Hypotheses and molecular mechanisms of action. Environ Health Perspect 110: pp. 103-112
  139. Cho, YS, Moon, HB (2010) The role of oxidative stress in the pathogenesis of asthma. Allergy Asthma Immunol Res 2: pp. 183-187
  140. Li, N, Sioutas, C, Cho, A, Schmitz, D, Misra, C, Sempf, J, Wang, M, Oberley, T, Froines, J, Nel, A (2003) Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111: pp. 455-460
  141. Nel, AE, Diaz-Sanchez, D, Li, N (2001) The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med 7: pp. 20-26
  142. Ghabaee, M, Bayati, A (2009) Saroukolaei SA, Sahraian MA, Sanaati MH, Karimi P, Houshmand M, Sadeghian H, Hashemi Chelavi L. Analysis of HLA DR2&DQ6 (DRB1* 1501, DQA1* 0102, DQB1* 0602) haplotypes in Iranian patients with multiple sclerosis. Cell Mol Neurobiol 29: pp. 109-114
  143. Rezaee, AR, Azadi, A, Houshmand, M, Mahmoodi, F, Purpak, Z, Safaei, S, Karimi, P, Ghabaee, M, Sahraian, MA (2012) Mitochondrial and nuclear genes as the cause of complex I deficiency. Genet Mol Res 12: pp. 3551-3554
  144. Vattanasit, U, Navasumrit, P, Khadka, MB, Kanitwithayanun, J, Promvijit, J, Autrup, H, Ruchirawat, M (2014) Oxidative DNA damage and inflammatory responses in cultured human cells and in humans exposed to traffic-related particles. Int J Hyg Environ Health 217: pp. 23-33
  145. Chu S, Zhang H, Maher C, McDonald JD, Zhang X, Ho SM, Yan B, Chillrud S, Perera F, Factor P, Miller RL. Prenatal and postnatal polycyclic aromatic hydrocarbon exposure, airway hyperreactivity, and Beta-2 adrenergic receptor function in sensitized mouse offspring. J Toxicol. 2013. doi:10.1155/2013/603581 .
  146. Jedrychowski, WA, Perera, FP, Maugeri, U, Majewska, R, Mroz, E, Flak, E, Camann, D, Sowa, A, Jacek, R (2015) Long term effects of prenatal and postnatal airborne PAH exposures on ventilatory lung function of non-asthmatic preadolescent children. Prospective birth cohort study in Krakow. Sci Total Environ 502: pp. 502-509
  147. Sram, RJ, Binkova, B, Dostal, M, Merkerova-Dostalova, M, Libalova, H, Milcova, A, Rossner, P, Rossnerova, A, Schmuczerova, J, Svecova, V, Topinka, J, Votavova, H (2013) Health impact of air pollution to children. Int J Hyg Environ Health 216: pp. 533-540
  148. Perera, F, Herbstman, J (2011) Prenatal environmental exposures, epigenetics, and disease. Reprod Toxicol 31: pp. 363-373
  149. Brown, LNA, Khousbouei, H, Goodwin, JS, Irvin-Wilson, CV, Ramesh, A, Sheng, L, McCallister, MM, Jiang, GC, Aschner, M, Hood, DB (2007) Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo pyrene. Neurotoxicology 28: pp. 965-978
  150. Rusling, JF, Kumar, CV, Gutkind, JS, Patel, V (2010) Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst. 135: pp. 2496-2511
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Epidemiology
  Public Health
  Infectious Diseases
  Cardiology
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7284

文摘

Asthma is the most common chronic illness in children living in developed countries and the leading cause of childhood hospitalization and school absenteeism. Prevalence rates of asthma are increasing and show disparities across gender, geographic regions, and ethnic/racial groups. Common risk factors for developing childhood asthma include exposure to tobacco smoke, previous allergic reactions, a family history of asthma, allergic rhinitis or eczema, living in an urban environment, obesity and lack of physical exercise, severe lower respiratory tract infections, and male gender. Asthma exacerbation in children can be triggered by a variety of factors, including allergens (e.g., pollen, dust mites, and animal dander), viral and bacterial infections, exercise, and exposure to airway irritants. Recent studies have shown that exposure to polycyclic aromatic hydrocarbons (PAHs), a major component of fine particulate matter from combustion sources, is also associated with onset of asthma, and increasing asthmatic symptoms. In this paper, we review sources of childhood PAH exposure and the association between airborne PAH exposure and childhood asthma prevalence and exacerbation.