Molecular mechanisms of experience-dependent structural and functional plasticity in the brain
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- 作者：Makoto Kondo
- 关键词：Environmental enrichment ; KIF1A ; Exercise ; 5 ; HT3 receptor ; Fear extinction
- 刊名：Anatomical Science International
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：92
- 期：1
- 页码：1-17
- 全文大小：
- 刊物主题：Anatomy; Human Physiology; Neurosciences; Cell Biology; Animal Anatomy / Morphology / Histology; Animal Physiology;
- 出版者：Springer Japan
- ISSN：1447-073X
- 卷排序：92
文摘
Experiences and environments have a variety of effects on brain plasticity at levels ranging from the molecular and cellular to the behavioral. Brain plasticity is one of the most important characteristics of animal survival. In particular, environmental enrichment and exercise induce many structural and functional changes in the brain, and it is noteworthy that these changes result in further beneficial effects at behavioral levels, such as improved learning behavior and antidepressant effects. The effects of enrichment and exercise, and the mechanisms involved in both, provide crucial evidence for the prevention and treatment of brain disorders. However, the enriched environment- and exercise-induced mechanisms underlying the structural and behavioral effects in the brain remain poorly understood. In this review I discuss the molecular mechanisms of environment- and experience-dependent brain plasticity based on the results of studies carried out by our research group at the Department of Neuroscience and Cell Biology, Osaka University. This review consists of three parts: first, a description of a role for the motor protein KIF1A in enhanced synaptogenesis and memory function induced by environmental enrichment; second, a discussion of the function of the 5-HT3 receptor in hippocampal neurogenesis and behavioral changes induced by exercise; third, a discussion of the role of the 5-HT3 receptor in fear extinction.