Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

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• 作者：Manali Mukherjee ; Hui Fang Lim ; Sruthi Thomas…
• 关键词：Mepolizumab ; Autoantibodies ; Autoimmune ; Eosinophilic asthma ; IL ; 5 ; Sputum ; Immune complex
• 刊名：Allergy, Asthma & Clinical Immunology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：13
• 期：1
• 全文大小：1553KB
• 刊物主题：Allergology; Immunology; Pneumology/Respiratory System;
• 出版者：BioMed Central
• ISSN：1710-1492
• 卷排序：13

文摘

BackgroundAnti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for severe eosinophilic asthma.