Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway

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• 作者：Jinju Wang ; Yusen Chen ; Yi Yang ; Xiang Xiao ; Shuzhen Chen ; Cheng Zhang…
• 关键词：EPCs ; NPCs ; Cerebral ECs ; Co ; culture ; PI3K/Akt signal pathway ; Hypoxia ; reoxygenation injury ; VEGFR2 ; VEGF ; BDNF
• 刊名：Molecular Brain
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：9
• 期：1
• 全文大小：2,846 KB
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• 作者单位：Jinju Wang (1)
  Yusen Chen (2)
  Yi Yang (3)
  Xiang Xiao (1)
  Shuzhen Chen (1)
  Cheng Zhang (1)
  Bradley Jacobs (4)
  Bin Zhao (2)
  Ji Bihl (1)
  Yanfang Chen (1) (2) (4) (5)
  
  1. Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Hwy, Dayton, OH, 45435, USA
  2. Department of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, Guangdong, China
  3. Wuhan Institute of Physical Education, College of Health Science, Wuhan, 430079, Hubei, China
  4. Department of Neurology, Wright State University, 3640 Colonel Glenn Hwy, Dayton, 45435, Ohio, USA
  5. Department of Internal Medicine, Wright State University, 3640 Colonel Glenn Hwy, Dayton, 45435, Ohio, USA
  
• 刊物主题：Neurosciences; Neurology;
• 出版者：BioMed Central
• ISSN：1756-6606

文摘

Background Protection of cerebral endothelial cells (ECs) from hypoxia/reoxygenation (H/R)-induced injury is an important strategy for treating ischemic stroke. In this study, we investigated whether co-culture with endothelial progenitor cells (EPCs) and neural progenitor cells (NPCs) synergistically protects cerebral ECs against H/R injury and the underlying mechanism.