High caloric intake, poor cognition and dementia: the Caerphilly Prospective Study

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• 作者：Samuel Thomas Creavin (1) samcreavin@nhs.net
  John Gallacher (2) gallacher@cf.ac.uk
  Janet Pickering (6)
  Ann Fehily (7)
  Mark Fish (3) Mark.Fish@tst.nhs.uk
  Shah Ebrahim (4) shah.ebrahim@lshtm.ac.uk
  Antony Bayer (5) bayer@cf.ac.uk
  Yoav Ben-Shlomo (1) Y.Ben-Shlomo@bristol.ac.uk
• 关键词：Epidemiology &#8211 ; Cognitive diseases &#8211 ; Energy intake* &#8211 ; Risk factors
• 刊名：European Journal of Epidemiology
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：27
• 期：3
• 页码：197-203
• 全文大小：195.8 KB
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• 作者单位：1. School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS UK2. Department of Primary Care and Public Health, Neuadd Meirionnydd, Heath Park, Cardiff, CF14 4YS UK3. Department of Neurology, Musgrove Park Hospital, Taunton, Somerset TA1 5DA, UK4. London School of Hygiene and Tropical Medicine, Room 116, Keppel St, London, WC1E 7HT UK5. Section of Geriatric Medicine, Academic Centre, University Hospital Llandough, Cardiff University School of Medicine, Penlan Road, Cardiff, CF64 2XX UK6. Department of Epidemiology Statistics and Public Health, Cardiff University, Cardiff, UK7. Tinuviel Software, Anglesey, UK
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Epidemiology
  Public Health
  Infectious Diseases
  Cardiology
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7284

文摘

To examine the hypothesis that caloric intake in mid-life is associated with later dementia or cognitive impairment not dementia (CIND). A prospective cohort study was conducted in Caerphilly, South Wales, United Kingdom. Men aged 45–59 years were identified from the electoral roll and general practice. 2,512 men were examined between July 1979 until September 1983. Four follow-up examinations were conducted every 4–5 years until 2004. Participants were categorized on the basis of their average daily caloric intake over each of the first three phases. Outcomes were CIND and dementia ascertained at phase five (2004). 192 men (15% of 1,248 participants at phase five) had CIND and 100 (8%) dementia. Age adjusted odds ratios demonstrated strongest associations between average energy consumption and vascular CIND or dementia (OR 1.62 95% CI 1.25–2.10). Adjustment for nutritional factors, vascular disease, diabetes, smoking, BP and BMI if anything increased the association (OR 1.64, 95% CI 1.03–2.60). After adjusting for social class, associations were attenuated and consistent with chance (OR 1.48, 95% CI 0.92–2.38). When adjusted for social class, the previously observed association between caloric intake and cognitive outcomes is modest, consistent with chance, and may be due to residual confounding.