The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network

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• 作者：Diana E. Schendel (1) dschendel@cdc.gov
  Carolyn DiGuiseppi (2)
  Lisa A. Croen (3)
  M. Daniele Fallin (4)
  Philip L. Reed (5)
  Laura A. Schieve (1)
  Lisa D. Wiggins (1)
  Julie Daniels (6)
  Judith Grether (7)
  Susan E. Levy (8)
  Lisa Miller (9)
  Craig Newschaffer (10)
  Jennifer Pinto-Martin (11)
  Cordelia Robinson (12)
  Gayle C. Windham (7)
  Aimee Alexander (1)
  Arthur S. Aylsworth (13)
  Pilar Bernal (14)
  Joseph D. Bonner (5)
  Lisa Blaskey (8)
  Chyrise Bradley (15)
  Jack Collins (3)
  Casara J. Ferretti (8)
  Homayoon Farzadegan (4)
  Ellen Giarelli (16)
  Marques Harvey (1)
  Susan Hepburn (12)
  Matthew Herr (15)
  Kristina Kaparich (12)
  Rebecca Landa (17)
  Li-Ching Lee (4)
  Brooke Levenseller (16)
  Stacey Meyerer (4)
  Mohammad H. Rahbar (18)
  Andria Ratchford (9)
  Ann Reynolds (12)
  Steven Rosenberg (12)
  Julie Rusyniak (17)
  Stuart K. Shapira (1)
  Karen Smith (7)
  Margaret Souders (16)
  Patrick Aaron Thompson (5)
  Lisa Young (16)
  Marshalyn Yeargin-Allsopp (1)
• 关键词：Autism &#8211 ; Epidemiology &#8211 ; Study methods &#8211 ; Risk factors &#8211 ; Phenotype
• 刊名：Journal of Autism and Developmental Disorders
• 出版年：2012
• 出版时间：October 2012
• 年：2012
• 卷：42
• 期：10
• 页码：2121-2140
• 全文大小：385.0 KB
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• 作者单位：1. National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Road, MS E-86, Atlanta, GA 30333, USA2. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, CO, USA3. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA4. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA5. Clinical and Translational Sciences Institute, Michigan State University, East Lansing, MI, USA6. Departments of Epidemiology and Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA7. Division of Environmental and Occupational Disease Control, CA Department of Public Health, Oakland, CA, USA8. Center for Autism, Children鈥檚 Hospital of Philadelphia, Philadelphia, PA, USA9. Colorado Department of Public Health and Environment, Denver, CO, USA10. Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA11. University of Pennsylvania School of Nursing and School of Medicine, Philadelphia, PA, USA12. University of Colorado Denver, School of Medicine, Denver, CO, USA13. Departments of Pediatrics and Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA14. Autism Spectrum Disorders Center, San Jose Medical Center, Kaiser Permanente Northern California, Oakland, CA, USA15. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA16. University of Pennsylvania School of Nursing, Philadelphia, PA, USA17. Kennedy Krieger Institute and Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA18. Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas School of Public Health at Houston, Houston, TX, USA
• ISSN：1573-3432

文摘

The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal, gastrointestinal, and sociodemographic characteristics. SEED uses a case–control design with population-based ascertainment of children aged 2–5 years with an autism spectrum disorder (ASD) and children in two control groups—one from the general population and one with non-ASD developmental problems. Data from parent-completed questionnaires, interviews, clinical evaluations, biospecimen sampling, and medical record abstraction focus on the prenatal and early postnatal periods. SEED is a valuable resource for testing hypotheses regarding ASD characteristics and causes.