Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer
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- 作者：Sergio Alonso ; Beatriz González ; Tatiana Ruiz-Larroya…
- 关键词：ADAMTS ; Methylation ; Matrix metallopeptidases ; Gastrointestinal cancer ; Ovarian cancer ; MS ; AFLP
- 刊名：Clinical Epigenetics
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：7
- 期：1
- 全文大小：3,093 KB
- 刊物主题：Human Genetics; Gene Function;
- 出版者：BioMed Central
- ISSN：1868-7083
文摘
Background ADAMTS19 encodes a member of the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) protein family with emerging roles in carcinogenesis and metastasis. ADAMTS shares several distinct protein modules including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. In a previous work, we found ADAMTS19 frequently hypermethylated in colorectal cancer (CRC). We explored the association of methylation with tumor genotype and phenotype.