Spatiotemporal variation of mammalian protein complex stoichiometries
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- 作者：Alessandro Ori ; Murat Iskar ; Katarzyna Buczak ; Panagiotis Kastritis…
- 关键词：Protein complex ; Stoichiometry ; Proteomics ; Paralog ; Epigenetic ; Transport ; Reprogramming ; Cancer
- 刊名：Genome Biology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：17
- 期：1
- 全文大小：1,774 KB
- 刊物主题：Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Microbial Genetics and Genomics; Fungus Genetics; Bioinformatics;
- 出版者：BioMed Central
- ISSN：1465-6906
文摘
Background Recent large-scale studies revealed cell-type specific proteomes. However, protein complexes, the basic functional modules of a cell, have been so far mostly considered as static entities with well-defined structures. The co-expression of their members has not been systematically charted at the protein level.