Human amniotic epithelial cells inhibit granulosa cell apoptosis induced by chemotherapy and restore the fertility

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• 作者：Qiuwan Zhang ; Minhua Xu ; Xiaofen Yao ; Ting Li ; Qian Wang…
• 刊名：Stem Cell Research & Therapy
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：6
• 期：1
• 全文大小：3,552 KB
• 刊物主题：Stem Cells; Cell Biology;
• 出版者：BioMed Central
• ISSN：1757-6512

文摘

Introduction Premature ovarian failure and insufficiency are significant long-term side-effects of chemotherapy for female cancer patients. Recently, stem cell transplantation has been identified as a promising treatment for premature ovarian failure and insufficiency. We have previously demonstrated that human amniotic epithelial cells (hAECs) migrate into injured tissue and promote the recovery of ovarian function in chemoablated mice. However, the molecular mechanism guiding this process remains unclear.