MiR-26a and miR-138 block the G1/S transition by targeting the cell cycle regulating network in prostate cancer cells
详细信息 查看全文
- 作者：Kati Erdmann ; Knut Kaulke ; Christiane Rieger…
- 关键词：Cell cycle ; Enhancer of zeste homolog 2 (EZH2) ; MicroRNAs ; MiR ; 138 ; MiR ; 26a ; Prostate cancer
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：142
- 期：11
- 页码：2249-2261
- 全文大小：1,247 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Oncology
Cancer Research
Internal Medicine
Hematology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1335
- 卷排序：142
文摘
PurposeThe tumor-suppressive microRNAs miR-26a and miR-138 are significantly down-regulated in prostate cancer (PCa) and have been identified as direct regulators of enhancer of zeste homolog 2 (EZH2), which is a known oncogene in PCa. In the present study, the influence of miR-26a and miR-138 on EZH2 and cellular function including the impact on the cell cycle regulating network was evaluated in PCa cells.