Magnetic resonance spectroscopy in neonatal hypoxic-ischaemic insults

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• 作者：Ernest B. Cady
• 关键词：Keywords  ; Magnetic resonance spectroscopy ; Neonatal ; Brain ; Hypoxia ; ischaemia ; Prognosis ; Cerebroprotection
• 刊名：Child's Nervous System
• 出版年：2001
• 出版时间：February 2001
• 年：2001
• 卷：17
• 期：3
• 页码：145-149
• 全文大小：31 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health<br>Neurosurgery<br>Neurosciences<br>
• 出版者：Springer Berlin / Heidelberg
• ISSN：1433-0350

文摘

This article aims to review the major achievements of phosphorus (31P) and proton (1H) magnetic resonance spectroscopy (MRS) in the field of perinatal hypoxic-ischaemic cerebral injury. Methodologies for applying MRS to the routine study of the infant brain are now well developed. Both 31P and 1H MRS reveal gross abnormalities in severe hypoxic-ischaemic injury – in 31P studies [phosphocreatine] and [adenosine triphosphate] are low whilst [inorganic phosphate] is high; 1H MRS reveals high [lactate] and reduced [N-acetylaspartate]. The 31P abnormalities are not apparent in early spectra but develop after 12–24 h – a phenomenon termed ”secondary energy failure”. These metabolic changes have now been modelled, and investigations of cerebroprotective therapies are underway. Extensive long-term studies have revealed that both 31P and 1H MRS, performed within a few days of birth, have great prognostic utility.