Immediate and Delayed Hypersensitivity Reactions to Proton Pump Inhibitors: Evaluation and Management
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  • 作者：Iris M. Otani ; Aleena Banerji
  • 关键词：Drug allergy ; Hypersensitivity reaction ; Adverse drug reaction ; Proton pump inhibitor ; PPI ; Skin testing ; Patch testing
  • 刊名：Current Allergy and Asthma Reports
  • 出版年：2016
  • 出版时间：March 2016
  • 年：2016
  • 卷：16
  • 期：3
  • 全文大小：902 KB
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  • 作者单位：Iris M. Otani (1)
    Aleena Banerji (1)

    1. Department of Medicine, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, USA
  • 刊物主题：Allergology;
  • 出版者：Springer US
  • ISSN：1534-6315
    • 文摘
    PPIs are among the most commonly administered medications in the USA and are generally well tolerated. Immediate and delayed immune-mediated hypersensitivity reactions are rare but increasingly recognized adverse effects of proton pump inhibitors (PPIs). Immediate hypersensitivity reactions can occur due to IgE-mediated hypersensitivity to PPIs and can be evaluated by immediate hypersensitivity skin testing and oral provocation challenge testing. A desensitization protocol can be used when PPI use cannot be avoided in an allergic patient. Delayed hypersensitivity reactions to PPIs have also been reported. Occupational exposures causing cutaneous reactions to PPIs are the most commonly reported delayed hypersensitivity reaction, followed by drug-induced subacute cutaneous lupus erythematosus. This review presents a summary of the clinical presentation, diagnostic evaluation, and management of immune-mediated hypersensitivity reactions to PPIs. Keywords Drug allergy Hypersensitivity reaction Adverse drug reaction Proton pump inhibitor PPI Skin testing Patch testing

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