Cysticlean? a highly pac standardized content in the prevention of recurrent urinary tract infections: an observational, prospective cohort study

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• 作者：Francisco Sánchez Ballester (1) (2)
  Vicente Ruiz Vidal (3)
  Emilio López Alcina (1) (2)
  Cristina Domenech Perez (4)
  Eva Escudero Fontano (2)
  Ana María Oltra Benavent (5)
  Ana Montoliu García (2)
  Marco Andrés Sobrón Bustamante (2)
  
• 关键词：Cranberry ; Cysticlean? ; Cystitis ; Postcoital ; QoL ; Urinary tract infections
• 刊名：BMC Urology
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：247KB
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  37. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/13/28/prepub
  
• 作者单位：Francisco Sánchez Ballester (1) (2)
  Vicente Ruiz Vidal (3)
  Emilio López Alcina (1) (2)
  Cristina Domenech Perez (4)
  Eva Escudero Fontano (2)
  Ana María Oltra Benavent (5)
  Ana Montoliu García (2)
  Marco Andrés Sobrón Bustamante (2)
  
  1. Urodynamics Unit, Hospital Quirón, Avenida de Vicente Blasco Iba?ez 14, 46010, Valencia, Spain
  2. Urology Department, Consorcio Hospital General Universitario, Valencia, Spain
  3. Primary Health Care, Clínica Comarcal Atenea Aldaia, Valencia, Spain
  4. Urology Department Hospital de la Malvarrosa, University of Valencia, Valencia, Spain
  5. Nephrology Department, Hospital Lluis Alcanyis de Xativa, Valencia, Spain
  

文摘

Background The present study was aimed at determining the prophylactic efficacy of American cranberry (AC) extract (Cysticlean?) in women with recurrent symptomatic postcoital urinary tract infections (PCUTI), non-consumer of AC extract in the past 3 months before inclusion, and to determine changes in their quality of life (QoL). Methods This was a single center, observational, prospective study in a total of 20 women (mean age 35.2 years; 50.0% were married). Patients were followed up for 3 and 6 months during treatment. Results The number of PCUTIs in the previous 3 months prior to start the treatment with Cysticlean? was 2.8±1.3 and it was reduced to 0.2±0.5 at Month 6 (P<0.0001), which represent a 93% improvement. At baseline, the mean score on the VAS scale (range from 0 to 100) for assessing the QoL was 62.4±19.1, increasing to 78.2±12.4 at Month 6 (P=0.0002), which represents a 20% improvement. All patients had an infection with positive urine culture at baseline, after 6 months there were only 3 symptomatic infections (P<0.001). The most common bacterium was Escherichia coli. Conclusions Prophylaxis with American cranberry extract (Cysticlean?) could be an alternative to classical therapies with antibiotics. Further studies are needed to confirm results obtained in this pilot study.