Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma
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- 作者：Yan-li Guo ; Bao-En Shan ; Wei Guo ; Zhi-Ming Dong ; Zhen Zhou…
- 关键词：Esophageal squamous cell carcinoma ; DACT gene ; Methylation ; Prognosis
- 刊名：Journal of Biomedical Science
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：24
- 期：1
- 全文大小：4323KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine, general;
- 出版者：BioMed Central
- ISSN：1423-0127
- 卷排序：24
文摘
BackgroundThe DACT (Dishevelled-associated antagonist of β-catenin) family of scaffold proteins may play important roles in tumorigenesis. However, the epigenetic changes of DACT1, 2, 3 and their effect on esophageal squamous cell carcinoma (ESCC) have not been investigated so far. The aim of this study was to investigate the promoter methylation and expression of DACT family, in order to elucidate more information on the role of DACT with regard to the progression and prognosis of ESCC.