Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett’s esophagus, and high-grade dysplasia/esophageal adenocarcinoma
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- 作者：Matthew F. Buas ; Haiwei Gu ; Danijel Djukovic ; Jiangjiang Zhu ; Lynn Onstad…
- 关键词：Barrett’s esophagus ; Esophageal adenocarcinoma ; Gastroesophageal reflux disease ; Metabolomics ; Serum biomarkers ; Risk stratification
- 刊名：Metabolomics
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：13
- 期：3
- 全文大小：
- 刊物主题：Biochemistry, general; Molecular Medicine; Cell Biology; Developmental Biology; Biomedicine, general;
- 出版者：Springer US
- ISSN：1573-3890
- 卷排序：13
文摘
Introduction/objectivesIncidence of esophageal adenocarcinoma (EA), an often fatal cancer, has increased sharply over recent decades. Several important risk factors (reflux, obesity, smoking) have been identified for EA and its precursor, Barrett’s esophagus (BE), but a key challenge remains in identifying individuals at highest risk, since most with reflux do not develop BE, and most with BE do not progress to cancer. Metabolomics represents an emerging approach for identifying novel biomarkers associated with cancer development.